Document Detail

Immunohistochemical study of oral lesions of lichen planus: diagnostic and pathophysiologic aspects.
MedLine Citation:
PMID:  1977114     Owner:  NLM     Status:  MEDLINE    
The immunophenotype of lymphoid cells in the epithelium and lamina propria of the oral mucosa were examined in patients with lichen planus, nondysplastic leukoplakia, leukoplakia with lichen planus, and other unrelated lesions. In all groups T lymphocytes were predominant; however, the T4/T8 lymphocyte ratio was higher with lichen planus than with other groups. This may be of diagnostic value in the histologic evaluation of oral lesions not typical of lichen planus. Finally, a higher percentage of Langerhans cells were observed in lichen planus. An immunologic pathogenesis of lichen planus is proposed.
S Boisnic; C Frances; M C Branchet; H Szpirglas; Y Le Charpentier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, and oral pathology     Volume:  70     ISSN:  0030-4220     ISO Abbreviation:  Oral Surg. Oral Med. Oral Pathol.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-15     Completed Date:  1990-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376406     Medline TA:  Oral Surg Oral Med Oral Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  D; IM    
Department of Stomatology, Groupe Hospitalier Pitie-Salpetriere, Paris, France.
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MeSH Terms
Aged, 80 and over
CD4-Positive T-Lymphocytes / immunology
Cell Count
HLA-DR Antigens / analysis
Keratinocytes / immunology
Langerhans Cells / immunology
Leukoplakia, Oral / immunology*,  pathology
Lichen Planus / immunology*,  pathology
Middle Aged
Mouth Diseases / immunology*,  pathology
Mouth Mucosa / immunology,  pathology
T-Lymphocyte Subsets*
T-Lymphocytes, Regulatory / immunology
Reg. No./Substance:
0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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