Document Detail

Immunohistochemical study of neuronal markers in human gingiva with phenytoin-induced overgrowth.
MedLine Citation:
PMID:  2457933     Owner:  NLM     Status:  MEDLINE    
The immunohistochemical occurrence of several different neuronal markers has been investigated in human gingiva with phenytoin-induced overgrowth. The material was compared to gingival material taken following surgical orthodontic treatment. Gingiva obtained from the phenytoin-treated groups seemed to have a reduced number of neurofilament (NF) immunoreactive nerve fibers in the propria compared to control material. In both phenytoin as well as control gingiva sparsely distributed, thin, calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactive fibers were found in the propria. No obvious differences between the two groups could be observed for CGRP and SP. Immunoreactive cells for somatostatin (SOM) with a dendritic cell shape were found in the propria in both groups, sometimes in densely packed clusters. A tendency for increase of SOM-immunoreactive cells in the phenytoin-treated gingiva was observed. A few gamma-melanocyte stimulating hormone (gamma-MSH)-immunoreactive cells with a round appearance were found in control as well as phenytoin-affected gingiva. In one instance, however, a heavy gamma-MSH-immunoreactive cell infiltration was seen in the phenytoin sample. No immunoreactivity in either the phenytoin-treated group or in the control group was seen for proctolin or galanin. The results indicated that gingiva with phenytoin-induced overgrowth has a reduced innervation density revealed with NF immunohistochemistry.
J Luthman; G Dahllöf; T Modèer; O Johansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of dental research     Volume:  96     ISSN:  0029-845X     ISO Abbreviation:  Scand J Dent Res     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-10-03     Completed Date:  1988-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0270023     Medline TA:  Scand J Dent Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  339-46     Citation Subset:  D; IM    
Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Calcitonin / analysis
Calcitonin Gene-Related Peptide
Gingiva / innervation*
Gingival Hyperplasia / chemically induced,  pathology*
Melanocyte-Stimulating Hormones / analysis
Nerve Fibers / ultrastructure*
Neurofibrils / ultrastructure
Neuropeptides / analysis
Phenytoin / adverse effects*
Somatostatin / analysis
Substance P / analysis
Reg. No./Substance:
0/Neuropeptides; 33507-63-0/Substance P; 51110-01-1/Somatostatin; 57-41-0/Phenytoin; 83652-28-2/Calcitonin Gene-Related Peptide; 9002-79-3/Melanocyte-Stimulating Hormones; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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