Document Detail

Immunohistochemical study on neuroglia identified by the monoclonal antibody against a macrophage differentiation antigen (Mac-1).
MedLine Citation:
PMID:  4044806     Owner:  NLM     Status:  MEDLINE    
We have studied frozen sections of the developing and adult mouse central nervous system (CNS), with or without cold lesions, by immunohistochemical and histochemical methods. Using a monoclonal antibody against a macrophage differentiation antigen (Mac-1), we have shown that some neuroglia in the white matter of adult mice stained positively. In the developing CNS, with or without cold lesioning, Mac-1-positive glia were not detected. In the normal adult CNS, a small number of glia in the white matter stained faintly. After cold injury, the number of Mac-1-positive glia and their staining intensity increased for several months. Mac-1-positive glia were always negative for glial fibrillary acidic protein (GFA). Their morphology and distribution were similar to those of nucleoside diphosphatase-positive cells. Considering that the phagocytic activity of glia increases after injury to the CNS (Trachtenberg 1983) and that Mac-1 has been reported to be associated with the complement receptor (Beller et al. 1982), Mac-1-positive glia may play a role in phagocytosis in the damaged CNS.
Y Matsumoto; K Watabe; F Ikuta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  9     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-10-28     Completed Date:  1985-10-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  379-89     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / immunology*
Antigens / immunology*
Central Nervous System / immunology
Glial Fibrillary Acidic Protein / immunology
Macrophages / immunology*
Mice, Inbred C3H
Neuroglia / immunology*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens; 0/Glial Fibrillary Acidic Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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