Document Detail

Immunohistochemical study of enterochromaffin-like cell in human gastric mucosa.
MedLine Citation:
PMID:  17685928     Owner:  NLM     Status:  MEDLINE    
Enterochromaffin-like (ECL) cell has been identified as the histamine-containing argyrophil cell in rat gastric mucosa and vigorously studied. However, there are few reports of the distribution of ECL cell in human stomach. The aim of the present study was to determine the precise distribution of ECL cell by immunohistochemical staining of histidine decarboxylase (HDC) and gastrin-cholecystokinin B receptor (CCK-BR) in human stomach, and the correlation between their distribution and that of parietal cells. Thirty specimens of surgically resected stomach were used. Parietal cell, Grimelius-silver-positive cell, gastrin, HDC- and CCK-BR-immunoreactive cell were studied on continuous cell counting in the restricted field along the lamina muscularis from the oral to the anal ends. The percentage of HDC-immunoreactive cells of endocrine cells was smaller (15%) than that of a previous report (35%) in the fundic region. HDC- and CCK-BR-immunoreactive cells were found not only in the fundic region, but also in the intermediate and pyloric regions. In the pyloric region, HDC- and CCK-BR-immunoreactive cells were found mainly in the mucosa with intestinal metaplasia. Double-positive cells were also found, but only in small numbers. This suggests that ECL cell, or a cell sharing its function, is present in the pyloric region.
Michiko Tanaka-Shintani; Makoto Watanabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  57     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-09     Completed Date:  2007-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  572-83     Citation Subset:  IM    
Faculty of Health Sciences, Kobe University School of Medicine, Sumaku, Kobe, Japan.
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MeSH Terms
Adenocarcinoma / metabolism,  pathology*,  surgery
Aged, 80 and over
Cell Count
Enterochromaffin Cells / metabolism*
Gastric Mucosa / metabolism,  pathology*
Gastrins / metabolism
Histidine Decarboxylase / metabolism
Immunoenzyme Techniques / methods*
Middle Aged
Neoplasm Proteins / metabolism
Receptor, Cholecystokinin B / metabolism
Stomach Neoplasms / metabolism,  pathology*,  surgery
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Gastrins; 0/Neoplasm Proteins; 0/Receptor, Cholecystokinin B; 0/Tumor Markers, Biological; EC Decarboxylase

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