| Immunohistochemical study on the distribution of homocysteine in the central nervous system of transgenic mice expressing a human Cu/Zn SOD mutation. | |
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MedLine Citation:
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PMID: 12650983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, we used the transgenic mice expressing a human Cu/Zn SOD mutation (SOD1(G93A)) as an in vivo model of ALS and performed immunohistochemical studies to investigate the changes of homocysteine in the central nervous system of symptomatic transgenic mice. In control and presymptomatic transgenic mice, homocysteine-immunoreactive astrocytes were not detected in any region. In symptomatic transgenic mice, homocysteine-immunoreactive astrocytes were distributed in the spinal cord, brainstem and cerebellar nuclei of transgenic mice. In the hippocampal formation of transgenic mice, pyramidal cells in the CA1-3 regions and granule cells in the dentate gyrus showed homocysteine immunoreactivity. The present study provides the first in vivo evidence that homocysteine immunoreactive astrocytes were found in the central nervous system of symptomatic SOD(G93A) transgenic mice, suggesting that reactive astrocytes may play an important role in the pathogenesis and progress of ALS. This study also suggests that increased expression of homocysteine in the hippocampal neurons might reflect a role of homocysteine in an abnormality of hippocampal function of ALS. |
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Authors:
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Yoon Hee Chung; Jin-Joo Hong; Chung Min Shin; Kyeung Min Joo; Myeung Ju Kim; Choong Ik Cha |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 967 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-24 Completed Date: 2003-06-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 226-34 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-799, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System / chemistry*, enzymology* Gene Expression Regulation, Enzymologic / physiology Homocysteine / analysis* Humans Immunochemistry Mice Mice, Transgenic Mutation / physiology* Superoxide Dismutase / biosynthesis*, genetics |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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