Document Detail


Immunohistochemical study of congenital gingival granular cell tumor (congenital epulis).
MedLine Citation:
PMID:  1962817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The congenital gingival granular cell tumor (CGGT) or congenital epulis is a rare lesion of unknown origin found only in newborn infants. The tumor consists mainly of large eosinophilic granular cells arranged in solid nests that are separated by thin fibrovascular areas. In addition, there are some spindle-shaped cells and medium-sized polygonal cells (so-called interstitial cells) among the neoplastic granular cells. Three CGGTs were investigated with a panel of poly- and monoclonal antibodies, using immunoperoxidase methods on formalin fixed paraffin embedded sections. Neoplastic granular cells of these three cases show cytoplasmic staining for neuron-specific enolase (NSE) and vimentin. However, all other reactions were negative. Our results suggest that the lesion may be derived from uncommitted nerve-related mesenchymal cells. On the other hand, interstitial cells show strong S-100 protein-, cytokeratin-, vimentin-, and NSE-immunostainings, and these cells are consistent with neuroendocrine nature. The presence of a biphasic cell population with granular cells and interstitial cells must be considered the main immunohistochemical feature.
Authors:
H Takahashi; S Fujita; H Satoh; H Okabe
Related Documents :
11521237 - Intrathyroidal water-clear cell parathyroid adenoma: a case report.
22358677 - The cell line data base and the new catalogue: detailed information on 2650 human and a...
9218707 - Detachment of glycolytic enzymes from cytoskeleton of melanoma cells induced by calmodu...
11830517 - Transendothelial function of human metastatic melanoma cells: role of the microenvironm...
21247657 - New insights into the mode of action of the actin adp-ribosylating virulence factors sa...
3664977 - Mechanisms of sinoatrial pacemaker synchronization: a new hypothesis.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  19     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-03-22     Completed Date:  1991-03-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  492-6     Citation Subset:  D; IM    
Affiliation:
Department of Oral Pathology, Nagasaki University School of Dentistry, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cytoplasm / chemistry,  ultrastructure
Epithelium / chemistry,  pathology
Female
Gingival Neoplasms / chemistry,  congenital*,  pathology
Humans
Immunoenzyme Techniques
Infant
Infant, Newborn
Neoplasms, Muscle Tissue / chemistry,  congenital*,  pathology
Phosphopyruvate Hydratase / analysis
Vimentin / analysis
Chemical
Reg. No./Substance:
0/Vimentin; EC 4.2.1.11/Phosphopyruvate Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Oral lesions in Mexican HIV-infected patients.
Next Document:  [Presynaptic augmentation induced by NaF in sympathetic ganglion of bullfrog].