Document Detail

Immunohistochemical study of congenital gingival granular cell tumor (congenital epulis).
MedLine Citation:
PMID:  1962817     Owner:  NLM     Status:  MEDLINE    
The congenital gingival granular cell tumor (CGGT) or congenital epulis is a rare lesion of unknown origin found only in newborn infants. The tumor consists mainly of large eosinophilic granular cells arranged in solid nests that are separated by thin fibrovascular areas. In addition, there are some spindle-shaped cells and medium-sized polygonal cells (so-called interstitial cells) among the neoplastic granular cells. Three CGGTs were investigated with a panel of poly- and monoclonal antibodies, using immunoperoxidase methods on formalin fixed paraffin embedded sections. Neoplastic granular cells of these three cases show cytoplasmic staining for neuron-specific enolase (NSE) and vimentin. However, all other reactions were negative. Our results suggest that the lesion may be derived from uncommitted nerve-related mesenchymal cells. On the other hand, interstitial cells show strong S-100 protein-, cytokeratin-, vimentin-, and NSE-immunostainings, and these cells are consistent with neuroendocrine nature. The presence of a biphasic cell population with granular cells and interstitial cells must be considered the main immunohistochemical feature.
H Takahashi; S Fujita; H Satoh; H Okabe
Related Documents :
11757867 - Myxoid and round cell liposarcoma: a spectrum of myxoid adipocytic neoplasia.
19476527 - Clear (pale) cell acanthosis as an incidental finding.
21244227 - Ultrastructural characterization of mouse embryonic stem cell-derived oocytes and granu...
21228047 - Evolution of the germ line-soma relationship in vertebrate embryos.
11197537 - Immunohistochemical analysis of development of desmin-positive hepatic stellate cells i...
10878317 - A simple protocol to evaluate nitrogen utilisation in saccharomyces cerevisiae.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  19     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-03-22     Completed Date:  1991-03-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  492-6     Citation Subset:  D; IM    
Department of Oral Pathology, Nagasaki University School of Dentistry, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cytoplasm / chemistry,  ultrastructure
Epithelium / chemistry,  pathology
Gingival Neoplasms / chemistry,  congenital*,  pathology
Immunoenzyme Techniques
Infant, Newborn
Neoplasms, Muscle Tissue / chemistry,  congenital*,  pathology
Phosphopyruvate Hydratase / analysis
Vimentin / analysis
Reg. No./Substance:
0/Vimentin; EC Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oral lesions in Mexican HIV-infected patients.
Next Document:  [Presynaptic augmentation induced by NaF in sympathetic ganglion of bullfrog].