| Immunohistochemical study of ceruloplasmin, lactoferrin and secretory component expression in neoplastic and non-neoplastic thyroid gland diseases. | |
| | |
MedLine Citation:
|
PMID: 11130016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The expression of lactoferrin (LF), ceruloplasmin (CP) and secretory component (SC) in various thyroid diseases was investigated using an immunohistochemical method. LF is an iron-binding protein overexpressed in certain human adenocarcinomas. CP is implicated in carcinogenesis and SC is part of the local immune defense system. Sections of 15 follicular adenomas, 5 follicular carcinomas (FC), 16 papillary carcinomas (PC), 15 goitres and 2 cases of lymphocytic thyroiditis were re-examined and investigated immunohistologically by a streptavidin-biotin method. A positive immunostain reaction for CP and LF was observed in all cases of PC and FC. A positive immunostain reaction for SC was observed in 13/16 cases of PC and 4/5 cases of FC. A negative immunostain reaction for CP, LF and SC was observed in medullary cancers, in follicular adenomas and in the cases with goitre. We conclude that the immunostain expression of LF, CP and SC is a valuable diagnostic aid in the differential diagnosis between benign and malignant thyroid tumors. The expression of SC indicates the presence of a local immunodefensive system. |
| | |
Authors:
|
A Kondi-Pafiti; V Smyrniotis; M Frangou; A Papayanopoulou; M Englezou; H Deligeorgi |
Related Documents
:
|
2743276 - Morphologic changes in the thyroid after irradiation for hodgkin's and non-hodgkin's ly... 16159996 - Hashimoto encephalopathy with pegylated interferon alfa-2b and ribavirin. 18926196 - Sialoblastoma. 6415596 - Acute symptoms of the aerodigestive tract caused by rapidly enlarging thyroid neoplasms. 23133166 - Jejunal diverticulae: reports of two cases with review of literature. 14745646 - Postcricoid hemangioma: an overlooked cause of dysphagia in infants?-a case report. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta oncologica (Stockholm, Sweden) Volume: 39 ISSN: 0284-186X ISO Abbreviation: Acta Oncol Publication Date: 2000 |
Date Detail:
|
Created Date: 2000-12-20 Completed Date: 2001-01-11 Revised Date: 2009-05-12 |
Medline Journal Info:
|
Nlm Unique ID: 8709065 Medline TA: Acta Oncol Country: Norway |
Other Details:
|
Languages: eng Pagination: 753-6 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Athens University, School of Medicine, Areteion Hospital, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma, Follicular
/
enzymology*,
pathology Adenoma / enzymology*, pathology Carcinoma, Papillary / enzymology*, pathology Ceruloplasmin / analysis* Diagnosis, Differential Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Lactoferrin / analysis* Secretory Component / analysis* Thyroid Diseases / enzymology*, pathology Thyroid Neoplasms / enzymology*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Lactoferrin; 0/Secretory Component; EC 1.16.3.1/Ceruloplasmin |
| Comments/Corrections | |
Comment In:
|
Acta Oncol. 2001;40(7):875-6
[PMID:
11859989
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Radiation therapy approach in gliomatosis cerebri--case reports and literature review.
Next Document: Surface active properties of polyoxyethylene macromonomers and their role in radical polymerization ...