Document Detail

Immunohistochemical studies of fetal trophoblast and maternal decidua in hydatidiform mole and choriocarcinoma.
MedLine Citation:
PMID:  3041405     Owner:  NLM     Status:  MEDLINE    
Immunohistochemical techniques have been used to investigate the expression of fetal trophoblast antigens and the maternal leucocytic response in molar pregnancy and choriocarcinoma. The antigenic phenotype of morphologically defined trophoblast populations in complete, partial and invasive moles was analogous to that in normal pregnancy. All trophoblast phenotypes described in normal pregnancy were also identified in choriocarcinoma, suggesting that extensive differentiation into heterogeneous subgroups occurs in malignant trophoblast. The maternal leucocytic infiltrate in molar pregnancy consisted of T lymphocytes and class II MHC-positive macrophages. CD2-positive, CD3-negative lymphocytes were identified in molar decidua but not in uterine tissue in choriocarcinoma. Similarly, endometrial granulocytes were present in molar decidua but not in choriocarcinoma; these cells were associated with decidualization rather than with fetal trophoblast.
J N Bulmer; P M Johnson; M Sasagawa; S Takeuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  9     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1988 Mar-Apr
Date Detail:
Created Date:  1988-08-29     Completed Date:  1988-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  183-200     Citation Subset:  IM    
Department of Pathology, University of Leeds, UK.
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MeSH Terms
Choriocarcinoma / analysis*
Decidua / analysis*
Hydatidiform Mole / analysis*
Immunoenzyme Techniques
Leukocytes / analysis
Trophoblasts / analysis*
Uterine Neoplasms / analysis*

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