Document Detail


Immunohistochemical studies of fetal trophoblast and maternal decidua in hydatidiform mole and choriocarcinoma.
MedLine Citation:
PMID:  3041405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunohistochemical techniques have been used to investigate the expression of fetal trophoblast antigens and the maternal leucocytic response in molar pregnancy and choriocarcinoma. The antigenic phenotype of morphologically defined trophoblast populations in complete, partial and invasive moles was analogous to that in normal pregnancy. All trophoblast phenotypes described in normal pregnancy were also identified in choriocarcinoma, suggesting that extensive differentiation into heterogeneous subgroups occurs in malignant trophoblast. The maternal leucocytic infiltrate in molar pregnancy consisted of T lymphocytes and class II MHC-positive macrophages. CD2-positive, CD3-negative lymphocytes were identified in molar decidua but not in uterine tissue in choriocarcinoma. Similarly, endometrial granulocytes were present in molar decidua but not in choriocarcinoma; these cells were associated with decidualization rather than with fetal trophoblast.
Authors:
J N Bulmer; P M Johnson; M Sasagawa; S Takeuchi
Related Documents :
10906875 - Treatment of myxoid liposarcoma in pregnancy.
21087335 - Fas-fasl system in molar pregnancy.
16183585 - Demographic variables of gestational trophoblastic disease in kwazulu-natal, south africa.
22608315 - Is the zona pellucida thickness of human embryos influenced by women's age and hormonal...
20491855 - Paroxysmal disorders in infancy and their risk factors in a population-based cohort: th...
5578235 - Fetal bile salt metabolism. i. the metabolism of sodium cholate-14c in the fetal dog.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  9     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1988 Mar-Apr
Date Detail:
Created Date:  1988-08-29     Completed Date:  1988-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  183-200     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Leeds, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Choriocarcinoma / analysis*
Decidua / analysis*
Female
Humans
Hydatidiform Mole / analysis*
Immunoenzyme Techniques
Immunohistochemistry
Leukocytes / analysis
Pregnancy
Trophoblasts / analysis*
Uterine Neoplasms / analysis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunoblot detection of enzyme proteins of peroxisomal beta-oxidation in fibroblasts, amniocytes, an...
Next Document:  Regulatory aspects of placental iron transfer--a comparative study.