| Immunohistochemical profile of common epithelial neoplasms arising in the kidney. | |
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MedLine Citation:
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PMID: 12613443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To distinguish common epithelial tumors arising in the kidney may have significant implications, in terms of molecular ontogeny and prognosis. It is important to investigate the distribution of immunoexpression of commonly used markers among renal neoplasms and to develop a useful panel as an adjunct to histologic examination, which could lead to the accurate diagnosis of both primary and metastatic tumors. Immunohistochemical stains for CD10, vimentin (VIM), E-cadherin (E-CD), cytokeratins (CK) 7, 8, 19, and 20, high molecular weight keratin (HCK), and peanut lectin agglutinin (PL) (Arachis hypogaea) were performed on 45 (96 for CK7, CK20) conventional (CC), 20 papillary (PC), and 6 (24 for CK7, CK20) chromophobe renal carcinomas (CPC); 12 oncocytomas (OC); 5 collecting duct carcinomas (CDC), and 25 urothelial carcinomas of the renal pelvis (UC). Reactivity for CD10 was evaluated on the basis of the presence of cell surface staining; that for all CKs, cytoplasmic/membranous staining; and that for PL, luminal staining. Both CD10 and VIM were predominantly expressed in CC and PC; E-CD in CPC, OC, and UC; CK7 in PC, CPC, and UC; CK8 and CK19 in CDC and UC; CK20 in UC; HCK in CDC and UC; and PL in CDC. CC and OC were predominantly CK7-/CK20-; PC, CK7+/20-; CPC, CK7+/CK20- or CK7-/CK20-; and UC, CK7+/CK20- or CK7+/CK20+. CDC showed slight predominance of CK7-/20- over CK7+/CK20-. CC was most frequently CD10+/CK7-/HCK-/PL-; PC, CD10+/CK7+/HCK-/PL-; CPC, CD10-/CK7+/HCK-/PL-; OC, CD10-/CK7-/HCK-/ PL-; CDC, CD10-/CK7+/HCK-/PL+ or CD10-/CK7-/ HCK+/PL+; and UC, CD10-/CK7+/HCK+/PL-. Discriminant analysis suggested that CD10/CK7/HCK/PL may be a useful primary immunopanel for distinguishing among CC, PC, CDC, and UC. |
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Authors:
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Mi-Kyung Kim; Seonwoo Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry Volume: 10 ISSN: 1541-2016 ISO Abbreviation: Appl. Immunohistochem. Mol. Morphol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-02-27 Completed Date: 2003-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888796 Medline TA: Appl Immunohistochem Mol Morphol Country: United States |
Other Details:
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Languages: eng Pagination: 332-8 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. mkkahn@u.washington.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma, Oxyphilic
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diagnosis,
metabolism,
pathology Cadherins / metabolism Carcinoma, Papillary / diagnosis, metabolism, pathology Carcinoma, Renal Cell / diagnosis, metabolism, pathology Humans Immunohistochemistry Keratins / chemistry, metabolism Kidney Neoplasms / diagnosis, metabolism*, pathology Neprilysin / metabolism Peanut Agglutinin / metabolism Prognosis Tumor Markers, Biological / metabolism Vimentin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cadherins; 0/Peanut Agglutinin; 0/Tumor Markers, Biological; 0/Vimentin; 68238-35-7/Keratins; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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