Document Detail


Immunohistochemical and molecular-pathological diagnosis of myocarditis in cases of suspected sudden infant death syndrome (SIDS)--a multicenter study.
MedLine Citation:
PMID:  19282217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Virus-induced myocarditis is a common disease even in infants and children, but diagnosis can be difficult according to the Dallas-criteria, which have been criticised as being too unreliable. The diagnosis has been substantially improved due to immunohistochemical techniques for characterization and quantification of myocardial inflammatory reactions as well as molecular-pathological methods for viral genome detection. The published studies report on post-mortem samples from SIDS victims and controls which were prospectively investigated. Pediatric cases of unnatural deaths served as controls. The results demonstrate a clearly higher prevalence of viral myocardial infections in cases of suspected SIDS. Preliminary criteria for cellular immunohistochemical diagnosis of viral myocardial affections derived from these findings were suggested.
Authors:
Reinhard Dettmeyer; Anne Baasner; Claudia Haag; Simone Bruch; Marc Schlamann
Related Documents :
7756807 - Sids cases have increased levels of interleukin-6 in cerebrospinal fluid.
1579657 - Plasma levels of dsip in infants in the first year of life and sids risk.
10817477 - Deprivation and sudden infant death syndrome.
10192307 - Maternal placental abnormality and the risk of sudden infant death syndrome.
18779297 - Associations of maternal fish intake during pregnancy and breastfeeding duration with a...
1621517 - Analysis of blood spot 17 alpha-hydroxyprogesterone concentration in premature infants-...
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-03-17
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  11 Suppl 1     ISSN:  1873-4162     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S124-7     Citation Subset:  IM    
Affiliation:
Institute of Forensic Medicine, University of Giessen, Frankfurter Street 58, D-35392 Giessen, Germany. Reinhard.Dettmeyer@forens.med.uni-giessen.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antigens, CD / analysis
Antigens, CD45 / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Capsid Proteins / analysis
Case-Control Studies
Female
Forensic Pathology
Humans
Immunohistochemistry
Infant
Leukocytes / immunology,  pathology
Macrophages / immunology,  pathology
Male
Myocarditis / diagnosis*,  virology*
Myocardium / pathology
Prospective Studies
Sudden Infant Death / etiology*
T-Lymphocytes / immunology,  pathology
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Capsid Proteins; 0/capsid protein VP1, parvovirus B19; EC 3.1.3.48/Antigens, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Apoptosis and gene expression after TBI.
Next Document:  Accidental fatal ingestion of colchicine-containing leaves--toxicological and histological findings.