| Immunohistochemical measurement of estrogen receptors in breast cancer tissue samples. | |
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MedLine Citation:
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PMID: 2425947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new estrogen receptor immunocytochemical assay (ER-ICA) which uses monoclonal antibodies to the estrogen receptor protein was applied to 97 breast cancer tissues. The results were correlated to those obtained by conventional dextran coated charcoal assays. The presence or absence of nuclear staining was significantly associated with positive or negative estrogen receptor status by dextran-coated charcoal (P less than 0.001). Furthermore ER-ICA results showed a high degree of correlation with a light microscopic grading. The relationship between ER-ICA results and response to endocrine therapies in patients with advanced disease was assessed in 20 patients. Six of 11 (55%) ER-ICA positive patients responded, whereas 8 of 9 (89%) ER-ICA negative patients failed. |
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Authors:
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W Jonat; H Maass; H E Stegner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer research Volume: 46 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4296s-4298s Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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diagnostic use Breast Neoplasms / analysis* Charcoal / diagnostic use Dextrans / diagnostic use Female Histocytochemistry Humans Immunoenzyme Techniques Receptors, Estrogen / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Receptors, Estrogen; 16291-96-6/Charcoal; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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