| Immunohistochemical markers for distinguishing Spitz nevi from malignant melanomas. | |
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MedLine Citation:
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PMID: 9310955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we demonstrate that immunostaining with MIB-1 and anti-bcl-2 is a useful tool to distinguish compound Spitz nevi from malignant melanomas. Forty-six cases of Spitz nevi and 50 cases of vertical growth-phase melanomas (Clark III-V) were compared for the immunoreactivity of MIB-1 and bcl-2 in the intradermal component of the lesions. As many as 76% of the Spitz nevus cases showed a low percentage (0-2%) of MIB-1 immunoreactivity. In the malignant melanomas, such a low MIB-1 index was shown in only 2% of the cases. The average MIB-1 index in malignant melanomas and Spitz nevi was 29.7 and 4.0%, respectively. bcl-2 was negative in only 4% of the melanoma cases, whereas the corresponding value was 72% in Spitz nevi. Statistical analyses using Students t test showed that the differences were highly significant (P < 0.001). By considering the immunoreactivity for MIB-1 and bcl-2 in the individual cases, we found that as many as 96% of the melanomas both expressed a bcl-2 positivity and exhibited a MIB-1 index exceeding 2% in the dermal component. The corresponding value was as low as 6% in the Spitz nevi. |
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Authors:
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L Kanter-Lewensohn; M A Hedblad; J Wejde; O Larsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Volume: 10 ISSN: 0893-3952 ISO Abbreviation: Mod. Pathol. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-11-06 Completed Date: 1997-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8806605 Medline TA: Mod Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 917-20 Citation Subset: IM |
Affiliation:
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Department of Tumor Pathology, Karolinska Institutet, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Nuclear Humans Immunohistochemistry Ki-67 Antigen Melanoma / chemistry* Nevus, Epithelioid and Spindle Cell / chemistry* Nuclear Proteins / analysis* Proto-Oncogene Proteins c-bcl-2 / analysis* Skin Neoplasms / chemistry* Tumor Markers, Biological / analysis Tumor Suppressor Protein p53 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Nuclear; 0/Ki-67 Antigen; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53 |
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