Document Detail


Immunohistochemical localization of somatostatin receptor type 2A in rat and human tissues.
MedLine Citation:
PMID:  11403108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we elucidated the cellular localization of somatostatin receptor (SSTR) by immunohistochemistry using an antibody specific for SSTR type 2A (SSTR2A) in various organs of rat and human. SSTR2A expression was basically similar in rat and human, except in the pancreas and adrenal cortex. In the pituitary gland, the posterior lobe and the majority of growth hormone cells and some ACTH and TSH cells expressed SSTR2A. In rat adrenal gland, the zona glomerulosa strongly expressed SSTR2A, whereas zone-specific immunoreactivity was not observed in human. The adrenal medulla moderately expressed SSTR2A in both rat and human. SSTR2A immunoreactivity was observed in islet cells and some ductal cells in human pancreas, and also in acinar cells of rat pancreas. In gastrointestinal (GI) tract, the majority of crypt cells and nerve plexuses strongly expressed SSTR2A. The number of SSTR2A positive cells was much more than that of chromogranin A positive endocrine cells. In the kidney, the glomerular capillaries and collecting tubules, but not proximal tubules, showed immunoreactivity. SSTR2A immunoreactivity was observed not only in endocrine cells but also in non-endocrine cells.
Authors:
N Kimura; M Schindler; N Kasai; I Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine journal     Volume:  48     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  IM    
Affiliation:
Department of Pathology and Laboratory Medicine, Tohoku Rosai Hospital, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / chemistry
Animals
Antibody Specificity
Digestive System / chemistry
Humans
Immunohistochemistry*
Islets of Langerhans / chemistry
Kidney / chemistry
Male
Organ Specificity
Pituitary Gland / chemistry
Rats
Receptors, Somatostatin / analysis*
Species Specificity
Tissue Distribution
Chemical
Reg. No./Substance:
0/Receptors, Somatostatin; 0/somatostatin receptor sst2A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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