| Immunohistochemical localization of prostaglandin synthase in the rat uterus and embryo during the peri-implantation period. | |
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MedLine Citation:
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PMID: 3129038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandins (PGs) appear to have a role in the appearance of the increased uterine vascular permeability and subsequent decidualization observed at implantation in many species. However, the sites of production of these PGs have not been clearly established. To clarify the PG synthetic capacity of the blastocyst and the various types of cells in the uterus at implantation, we have studied the immunohistochemical localization of PG synthase in the rat blastocyst on Days 5 to 7 and uterus on Days 1, 4, 5, 6, and 7 of pregnancy. Labeling of PG synthase was negligible in the uterus on Day 1 of pregnancy. On Day 4, there was increased labeling in the luminal and glandular epithelium, in stromal cells adjacent to the luminal epithelium, and in blood vessels and some leukocytes. PG synthase was detected in the blastocysts on Days 5 to 7, but there was a gradual loss of label in the luminal and glandular epithelial cells during this period. Early differentiating stromal cells adjacent to the luminal epithelium in the implantation site on Day 5 showed bright labeling, whereas peripheral stromal cells were only slightly labeled. By Day 7, the differentiated cells of the primary decidual zone showed little or no label, but cells in the secondary decidual zone were brightly labeled. These results indicate that PG synthase is present in the rat blastocyst and in several kinds of uterine cells, and that its localization in uterine cells changed markedly during the implantation process. |
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Authors:
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M B Parr; E L Parr; K Munaretto; M R Clark; S K Dey |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of reproduction Volume: 38 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-06-08 Completed Date: 1988-06-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 333-43 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Southern Illinois University School of Medicine, Carbondale 62901. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastocyst / enzymology* Embryo Implantation* Endothelium, Vascular / enzymology Epithelium / enzymology Female Fluorescent Antibody Technique Immunohistochemistry Pregnancy Prostaglandin-Endoperoxide Synthases / analysis* Rats Time Factors Tissue Distribution Uterus / blood supply, enzymology* |
| Grant Support | |
ID/Acronym/Agency:
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HD-13073/HD/NICHD NIH HHS; HD-17480/HD/NICHD NIH HHS; HD-22299/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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