Document Detail

Immunohistochemical localization of plasminogen activator inhibitor-1 in human coronary atherosclerotic lesions involved in acute myocardial infarction.
MedLine Citation:
PMID:  8407726     Owner:  NLM     Status:  MEDLINE    
Immunohistochemical localization of plasminogen activator inhibitor-1 (PAI-1) was studied using the streptavidin-biotin method in human atherosclerotic coronary arteries. The patients (one male and two females), whose ages ranged from 61 to 78 years, died of anteroseptal acute myocardial infarction without having received any thrombolytic therapy. PAI-1 immunoreactivities (IRs) were mainly detected in the endothelial cells, smooth muscle cells, and collagen fibers of the coronary arterial intima and not in thrombi. Remarkable immunohistochemical staining was seen in intimal collagen fibers. In one patient, intimal PAI-1 IRs partly bordered a thrombus and surrounded a large atheroma rich in cholesterol crystals. Our results suggest that PAI-1 is present in both cellular and extracellular components of human coronary atherosclerotic lesions.
K Yorimitsu; T Saito; T Toyozaki; T Ishide; N Ohnuma; Y Inagaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  8     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1993  
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  160-2     Citation Subset:  IM    
Third Department of Internal Medicine, Chiba University School of Medicine, Japan.
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MeSH Terms
Coronary Artery Disease / pathology*
Coronary Vessels / pathology
Immunoenzyme Techniques
Middle Aged
Myocardial Infarction / pathology*
Plasminogen Activator Inhibitor 1 / analysis*
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1

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