| Immunohistochemical localization of plasminogen activator inhibitor-1 in human coronary atherosclerotic lesions involved in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 8407726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunohistochemical localization of plasminogen activator inhibitor-1 (PAI-1) was studied using the streptavidin-biotin method in human atherosclerotic coronary arteries. The patients (one male and two females), whose ages ranged from 61 to 78 years, died of anteroseptal acute myocardial infarction without having received any thrombolytic therapy. PAI-1 immunoreactivities (IRs) were mainly detected in the endothelial cells, smooth muscle cells, and collagen fibers of the coronary arterial intima and not in thrombi. Remarkable immunohistochemical staining was seen in intimal collagen fibers. In one patient, intimal PAI-1 IRs partly bordered a thrombus and surrounded a large atheroma rich in cholesterol crystals. Our results suggest that PAI-1 is present in both cellular and extracellular components of human coronary atherosclerotic lesions. |
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Authors:
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K Yorimitsu; T Saito; T Toyozaki; T Ishide; N Ohnuma; Y Inagaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Heart and vessels Volume: 8 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 1993 |
Date Detail:
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Created Date: 1993-11-23 Completed Date: 1993-11-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: JAPAN |
Other Details:
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Languages: eng Pagination: 160-2 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Chiba University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Disease / pathology* Coronary Vessels / pathology Female Humans Immunoenzyme Techniques Male Middle Aged Myocardial Infarction / pathology* Plasminogen Activator Inhibitor 1 / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Plasminogen Activator Inhibitor 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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