Document Detail

Immunohistochemical localization of insulin-like growth factor-II in the perinatal rat gonad.
MedLine Citation:
PMID:  8745143     Owner:  NLM     Status:  MEDLINE    
To clarify the participation of insulin-like growth factor type-II (IGF-II) in rat gonadal differentiation, immunohistochemical localization of IGF-II was chronologically studied in Sprague-Dawley rat gonads from gestational day (GD) 13 to postnatal day (PD) 21 by using avidin-biotin complex technique. In male gonads, most cells were negative to IGF-II immunostaining during the perinatal period. Only Leydig/interstitial cells expressed positive reactivity from GD 21 to PD 11: the intensity of staining and the number of positive cells were gradually increased until PD 11. In female gonads, almost all cells showed negative immunoreactivity. Mesonephric tubules in both sexes exhibited slight or moderate reactivity on GD 13. These results indicate that IGF-II is likely to participate in the regression of fetal-type Leydig cells and/or the proliferation of adult-type Leydig cells around birth, and in the development of mesonephric tubules in the initial stage of gonadal differentiation.
S Koike; T Noumura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Growth regulation     Volume:  5     ISSN:  0956-523X     ISO Abbreviation:  Growth Regul.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-11     Completed Date:  1996-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9106990     Medline TA:  Growth Regul     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  185-89     Citation Subset:  IM    
Department of Regulation Biology, Saitama University, Japan.
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MeSH Terms
Aging / physiology*
Animals, Newborn
Antibodies, Monoclonal
Granulosa Cells / cytology
Immunoglobulin G
Immunohistochemistry / methods
Insulin-Like Growth Factor II / analysis*,  biosynthesis
Leydig Cells / cytology
Mice, Inbred BALB C / immunology
Ovary / cytology*,  embryology,  growth & development
Rats, Sprague-Dawley
Sensitivity and Specificity
Sertoli Cells / cytology
Sexual Maturation
Testis / cytology*,  embryology,  growth & development
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Immunoglobulin G; 67763-97-7/Insulin-Like Growth Factor II

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