Document Detail

Immunohistochemical localization of hormones and peptides in the human pituitary cells in a case of hypercortisolism by ACTH secreting microadenoma.
MedLine Citation:
PMID:  17455145     Owner:  NLM     Status:  MEDLINE    
This study assesses the action of hypercortisolism on the hormone and peptide periadenoma region of removed ACTH-producing microadenoma. Our findings show that cortisol excess affects both ACTH and GH production, with no immunoreaction for these hormones. The remaining pituitary hormones (TSH, FSH and PRL) and POMC-derived peptides (betaEnd, alphaMSH and betaMSH) were not modified. Likewise, we observed pituitary immunoreactive cells for Neurotensin (NT), Intestinal vasoactive peptide (VIP), Substance P (SP) and Angiotensin-II (Ang-II). The colocalization demonstrated that NT was expressed in thyrotrope and gonadotrope cells, VIP in gonadotrope cells and SP in corticotrope cells. The results about Ang-II were inconclusive. On the other hand, immunoreaction for the NPY and Gal peptides were not present. In the adenomatous cells, the peptide NT is present in ACTH cells as well as SP. These results suggest a peptide regulation of pituitary cells in the pathological state that can differ between normal and tumoural cells of the same pituitary.
R Reyes; F Valladares; L Díaz-Flores; L Feria; R Alonso; G Tramu; A R Bello
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  22     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  709-17     Citation Subset:  IM    
Section of Cell Biology, School of Biology, University of La Laguna, La Laguna, Spain.
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MeSH Terms
ACTH-Secreting Pituitary Adenoma / chemistry*,  complications,  pathology
Adenoma / chemistry*,  complications,  pathology
Adrenocorticotropic Hormone / analysis
Angiotensin II / analysis
Corticotrophs / chemistry
Cushing Syndrome / etiology*,  metabolism,  pathology
Gonadotrophs / chemistry
Human Growth Hormone / analysis
Neuropeptides / analysis*
Neurotensin / analysis
Pituitary Hormones / analysis*
Substance P / analysis
Thyrotrophs / chemistry
Vasoactive Intestinal Peptide / analysis
Reg. No./Substance:
0/Neuropeptides; 0/Pituitary Hormones; 11128-99-7/Angiotensin II; 12629-01-5/Human Growth Hormone; 33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 39379-15-2/Neurotensin; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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