Document Detail


Immunohistochemical localization of glutathione peroxidase in infarcted human brain.
MedLine Citation:
PMID:  8195806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This is the first report which demonstrates the presence of glutathione peroxidase in the autopsied brain of 5 patients without cerebral infarction and 21 patients with cerebral infarction by the indirect enzyme-labeled antibody technique with monoclonal antibody to human glutathione peroxidase. In 2 out of 5 patients without cerebral infarction, a weak reaction for glutathione peroxidase was demonstrated both in neurons and glia. In 6 patients who had died within 5 days after stroke, no staining was observed in infarcted brain tissue except in macrophages. In all 15 patients who had died more than 6 days after stroke, however, a reaction for glutathione peroxidase was demonstrated in the cytoplasm of glial cells in the marginal area around the infarction, and there was a patchy reaction in the cytoplasm of macrophages in the core lesion. These results suggest that glutathione peroxidase in glial cells of the marginal area around the infarction may play a protective role against lipid peroxidation after cerebral infarction, or alternatively, may be involved in the healing process after ischemia.
Authors:
S Takizawa; K Matsushima; Y Shinohara; S Ogawa; N Komatsu; H Utsunomiya; K Watanabe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  122     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-24     Completed Date:  1994-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  66-73     Citation Subset:  IM    
Affiliation:
Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal / analysis,  immunology
Brain / enzymology*,  pathology
Cerebral Infarction / enzymology*,  pathology
Female
Glutathione Peroxidase / immunology,  metabolism*
Humans
Immunohistochemistry
Male
Middle Aged
Neuroglia / enzymology
Neurons / enzymology
Superoxide Dismutase / metabolism
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

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