Document Detail


Immunohistochemical localization of the epidermal growth factor-receptor in rhesus-monkey prostate.
MedLine Citation:
PMID:  8766403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidermal growth-factor receptor (EGF-r), a membrane-bound glycoprotein activated by EGF, is important in maintaining the integrity and function of the prostate. To investigate EGF-r presence in the prostate of the rhesus monkey, monoclonal-antibody immunohistochemical examination was performed. The monkey prostate consisted of the cranial and caudal lobes, and the prostatic epithelial cells were composed of the secretory and basal cells. The distribution patterns of EGF-r in the prostatic epithelial cells were quite different between the cranial and caudal lobes. In the caudal lobe, EGF-r was seen in both secretory and basal cells, whereas, in the cranial lobe, the EGF-r was seen exclusively in the basal cells. The stromal cells of both lobes did not show EGF-r. This study revealed that each prostatic lobe contains specific binding sites for EGF, indicating a biological difference between the two lobes of the prostate of the rhesus monkey.
Authors:
S Wakui; M Furusato; S Sasaki; T Masaoka; S Ushigome; S Aizawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anatomia, histologia, embryologia     Volume:  25     ISSN:  0340-2096     ISO Abbreviation:  Anat Histol Embryol     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-09-16     Completed Date:  1996-09-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7704218     Medline TA:  Anat Histol Embryol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  109-11     Citation Subset:  IM    
Affiliation:
Comparative Toxicology Laboratories, Azabu University School of Veterinary Medicine, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / ultrastructure
Epithelial Cells
Immunoenzyme Techniques
Immunohistochemistry
Macaca mulatta
Male
Prostate / cytology*
Receptor, Epidermal Growth Factor / analysis*
Chemical
Reg. No./Substance:
EC 2.7.10.1/Receptor, Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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