Document Detail

Immunohistochemical localization of connective tissue growth factor in the rat central nervous system.
MedLine Citation:
PMID:  10407104     Owner:  NLM     Status:  MEDLINE    
Connective tissue growth factor (CTGF) is an immediate early growth-responsive gene but its distribution and significance in the central nervous system (CNS) are unknown. We investigated the distribution of CTGF-like immunoreactivity (CTGF-IR) in the rat CNS using a specific antiserum against CTGF oligopeptide. The majority of CTGF-IR was observed in astrocytes. Ependymal cells lining the wall of the cerebral ventricle and tanycytes lining the central canal of the spinal cord showed the strongest CTGF-IR, while there was a diffuse but weak signal in the gray matter of the spinal cord. CTGF-IR was also detected in the cytoplasm of a subpopulation of pyramidal neurons in the cerebral cortex. Our results showed that CTGF-IR is widely distributed in the CNS at both regional and cellular levels, suggesting a complex functional role in the CNS.
Y Kondo; T Nakanishi; M Takigawa; N Ogawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  834     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-10     Completed Date:  1999-09-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  146-51     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Elsevier Science B.V.
Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700-8558, Japan.
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MeSH Terms
Central Nervous System / metabolism*
Cerebral Cortex / cytology,  metabolism
Cerebral Ventricles / metabolism
Connective Tissue Growth Factor
Growth Substances / metabolism*
Immediate-Early Proteins*
Intercellular Signaling Peptides and Proteins*
Pyramidal Cells / metabolism
Rats, Sprague-Dawley
Spinal Cord / cytology,  metabolism
Tissue Distribution / physiology
Reg. No./Substance:
0/Ctgf protein, rat; 0/Growth Substances; 0/Immediate-Early Proteins; 0/Intercellular Signaling Peptides and Proteins; 139568-91-5/Connective Tissue Growth Factor

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