Document Detail

Immunohistochemical localization of c-fos in the nuclei of the medulla oblongata in relation to asphyxia.
MedLine Citation:
PMID:  10550592     Owner:  NLM     Status:  MEDLINE    
The immediately early gene product c-fos is known to be induced in neurons under noxious stimuli. Therefore, the immunohistochemistry of c-fos expression in human brains might offer information on the localization of stimulated neurons. In this study, the immunohistochemical localization of c-fos was studied in the neurons of the hypoglossal nucleus (XII), the dorsal motor nucleus of the vagal nerve (X), the nucleus solitarius (Sol), the accessory cuneate nucleus (Cun), the spinal trigeminal nucleus (V) and the inferior olive (Oli) of the human medulla oblongata from forensic autopsy cases. The neurons in the X nucleus showed the highest percentage of positive reactions for c-fos, followed in descending order by the Cun, V, Oli, XII and Sol. The c-fos immunoreactivity in the Cun and X was statistically significantly higher than in the Sol, XII and Oli. Although neurons in the Sol are known to be involved in respiration, there was no statistically significant difference in the c-fos immunoreactivity in the neurons in the Sol between asphyxia and non-asphyxia cases. On the other hand, the percentage of neurons positive for the c-fos immunoreactivity was statistically significantly higher in the Oli of asphyxia cases than of non-asphyxia cases. Our results indicate the difference in the immunoreactivity of c-fos among the nuclei of the human medulla oblongata and that the c-fos immunoreactivity in the Oli might assist the diagnosis of asphyxia.
M Nogami; A Takatsu; N Endo; I Ishiyama
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of legal medicine     Volume:  112     ISSN:  0937-9827     ISO Abbreviation:  Int. J. Legal Med.     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-09     Completed Date:  1999-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9101456     Medline TA:  Int J Legal Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  351-4     Citation Subset:  IM    
Department of Legal Medicine, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashiku, Tokyo, 173-8605, Japan.
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MeSH Terms
Aged, 80 and over
Asphyxia / pathology*
Child, Preschool
Drowning / pathology
Forensic Medicine*
Medulla Oblongata / metabolism*,  pathology
Middle Aged
Neurons / metabolism
Proto-Oncogene Proteins c-fos / analysis*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos

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