| Immunohistochemical localization of anterior pituitary hormones in S-100 protein-positive cells in the rat pituitary gland. | |
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MedLine Citation:
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PMID: 21830043 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the anterior and intermediate lobes of the rat pituitary gland, non-hormone-producing cells that express S-100 protein coexist with various types of hormone-producing cells and are believed to function as phagocytes, supporting and paracrine-controlling cells of hormone-producing cells and stem cells, among other functions; however, their cytological characteristics are not yet fully understood. Using a transgenic rat that expresses green fluorescent protein under the promoter of the S100β protein gene, we immunohistochemically detected expression of the luteinizing hormone, thyroid-stimulating hormone, prolactin, growth hormone and proopiomelanocortin by S-100 protein-positive cells located between clusters of hormone-producing cells in the intermediate lobe. These findings lend support to the hypothesis that S-100 protein-positive cells are capable of differentiating into hormone-producing cells in the adult rat pituitary gland. |
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Authors:
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Motoshi Kikuchi; Megumi Yatabe; Yukiko Tando; Takashi Yashiro |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-10 |
Journal Detail:
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Title: Cell and tissue research Volume: - ISSN: 1432-0878 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Education, Jichi Medical University School of Medicine, Yakushiji 3311-1, Shimotsuke-shi, Tochigi, 329-0498, Japan, kikuchim@jichi.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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