| Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies. | |
| | |
MedLine Citation:
|
PMID: 22273571 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
X-linked inhibitor of apoptosis protein (XIAP) blocks the apoptosis by binding to and inhibiting caspases-3, 7, and 9. XIAP is negatively regulated by the mitochondrial serine protease, HtrA2/Omi. The aim of this study was to investigate the role of XIAP and the relationship between XIAP and HtrA2/Omi in patients with Parkinson's disease or dementia with Lewy bodies. We conducted immunohistochemical studies on XIAP in formalin-fixed, paraffin-embedded sections from eight normal participants, 10 patients with Parkinson's disease, five patients with dementia with Lewy bodies, and seven patients with Alzheimer's disease, and then double-labeling immunohistochemistry for XIAP and HtrA2/Omi in sections from the Parkinson's disease and dementia with Lewy bodies cases. Brainstem-type and cortical Lewy bodies were intensely immunostained for XIAP, and XIAP immunoreactivity was localized to the halos of brainstem-type Lewy bodies and to the entire bodies of cortical Lewy bodies. Double immunofluorescence analyses showed that XIAP and HtrA2/Omi immunoreactivities were colocalized to both types of Lewy bodies. Our results suggest that XIAP may be partially associated with the pathogenesis of Parkinson's disease and dementia with Lewy bodies. |
| | |
Authors:
|
Yasuhiro Kawamoto; Hidefumi Ito; Masafumi Ihara; Ryosuke Takahashi |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Neuroreport Volume: 23 ISSN: 1473-558X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: - |
Other Details:
|
Languages: ENG Pagination: 162-167 Citation Subset: - |
Affiliation:
|
aDepartment of Neurology, Faculty of Medicine, Kyoto University bDepartment of Neurology, Seijinkai Rakusaishimizu Hospital, Kyoto, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selectivity requirements for diagnostic imaging of neurofibrillary lesions in Alzheimer's disease: A...
Next Document: Comparative hepatitis A seroepidemiology in 10 European countries.