| Immunohistochemical localization of Epstein-Barr virus receptor on hyperplastic gingiva of kidney allotransplant patient immunocompromised by cyclosporin A. | |
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MedLine Citation:
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PMID: 9590896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The strong association between Epstein-Barr Virus (EBV) and certain tumours of the oro-maxillo-laryngeal region aroused our present interest. A pre-requisite for the molecular interplay of oncogenesis by EBV is the expression of the EBV receptor on the target cell of the host. As a possible contribution to this concept, we adopted immunohistochemical technique to examine a hyperplastic gingival tissue obtained from a subject on kidney allotransplant immunosuppressed with cyclosporin A (CSA). Our results demonstrate expression of EBV/C3d receptor on the superficial layers of the hyperplastic gingiva but absent in the basal/parabasal layers. It is suggested that the superficial layer expression of EBV/C3d receptor could be due to direct acquisition from the environment of the oral cavity rather than a systemic extension from the deep layers of the same epithelium. |
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Authors:
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J A Akinwande; A A Kazeem; E O Taiwo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: African dental journal : official publication of the Federation of African Dental Associations = Journal dentaire africain / FADA Volume: 9 ISSN: 0794-7348 ISO Abbreviation: Afr Dent J Publication Date: 1995 |
Date Detail:
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Created Date: 1998-08-11 Completed Date: 1998-08-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8813229 Medline TA: Afr Dent J Country: NIGERIA |
Other Details:
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Languages: eng Pagination: 20-4 Citation Subset: D |
Affiliation:
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Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Nigeria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cyclosporine
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therapeutic use* Gingival Hyperplasia / metabolism* Herpesvirus 4, Human* Humans Immunocompromised Host / physiology* Immunoenzyme Techniques Immunohistochemistry Immunosuppressive Agents / therapeutic use* Kidney Transplantation / physiology* Receptors, Complement 3d / metabolism* Receptors, Virus / metabolism* Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Receptors, Complement 3d; 0/Receptors, Virus; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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