Document Detail

Immunohistochemical localization of Epstein-Barr virus receptor on hyperplastic gingiva of kidney allotransplant patient immunocompromised by cyclosporin A.
MedLine Citation:
PMID:  9590896     Owner:  NLM     Status:  MEDLINE    
The strong association between Epstein-Barr Virus (EBV) and certain tumours of the oro-maxillo-laryngeal region aroused our present interest. A pre-requisite for the molecular interplay of oncogenesis by EBV is the expression of the EBV receptor on the target cell of the host. As a possible contribution to this concept, we adopted immunohistochemical technique to examine a hyperplastic gingival tissue obtained from a subject on kidney allotransplant immunosuppressed with cyclosporin A (CSA). Our results demonstrate expression of EBV/C3d receptor on the superficial layers of the hyperplastic gingiva but absent in the basal/parabasal layers. It is suggested that the superficial layer expression of EBV/C3d receptor could be due to direct acquisition from the environment of the oral cavity rather than a systemic extension from the deep layers of the same epithelium.
J A Akinwande; A A Kazeem; E O Taiwo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  African dental journal : official publication of the Federation of African Dental Associations = Journal dentaire africain / FADA     Volume:  9     ISSN:  0794-7348     ISO Abbreviation:  Afr Dent J     Publication Date:  1995  
Date Detail:
Created Date:  1998-08-11     Completed Date:  1998-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8813229     Medline TA:  Afr Dent J     Country:  NIGERIA    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  D    
Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Nigeria.
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MeSH Terms
Cyclosporine / therapeutic use*
Gingival Hyperplasia / metabolism*
Herpesvirus 4, Human*
Immunocompromised Host / physiology*
Immunoenzyme Techniques
Immunosuppressive Agents / therapeutic use*
Kidney Transplantation / physiology*
Receptors, Complement 3d / metabolism*
Receptors, Virus / metabolism*
Transplantation, Homologous
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Receptors, Complement 3d; 0/Receptors, Virus; 59865-13-3/Cyclosporine

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