Document Detail

Immunohistochemical identification of plasma protein deposits in the wall of lenticulostriate arteries in patients with long-standing hypertension, with and without lipohyalinosis.
MedLine Citation:
PMID:  19330218     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate, through an immunohistochemical method, whether there is deposition of plasma proteins in the wall of lenticulostriate, cortical and leptomeningeal arteries of hypertensive patients, with and without lipohyalinosis. METHOD: Forty patients with essential hypertension were selected at random, 20 with lipohyalinosis in the lenticulostriate arteries (HH group) and 20 without lipohyalinosis (H group), matched with 20 normotensive controls (C group). RESULTS: Plasma protein deposits were identified in eight patients (40%) in the C group, in 15 patients (75%) in the H group, and in all 20 patients (100%) in the HH group, the difference being significant for the H group and highly significant for the HH group, as compared with the C group. In all groups, the distribution of plasma protein deposits, subendothelial in normal arteries, and diffuse, irregular in the wall of arteries with lipohyalinosis, was more frequent in the lenticulostriate arteries of the putamen. CONCLUSION: Deposition of plasma proteins in the lenticulostriate arteries seems to be relatively frequent in normotensive individuals, starting in middle age. Such process appears to be intensified by hypertension, especially in individuals with lipohyalinosis.
Magda Rocha Andrade; Jos? Eymard Homem Pittella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  67     ISSN:  1678-4227     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2010-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  82-9     Citation Subset:  IM    
Laboratory of Neuropathology, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
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MeSH Terms
Age Factors
Aged, 80 and over
Basal Ganglia / blood supply*,  pathology
Basal Ganglia Cerebrovascular Disease / pathology*
Blood Proteins / isolation & purification*
Case-Control Studies
Hyalin / metabolism
Hypertension / physiopathology*
Middle Aged
Middle Cerebral Artery / physiopathology*
Reg. No./Substance:
0/Blood Proteins; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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