Document Detail

Immunohistochemical identification of the cholecystokinin cell in the intestinal mucosa.
MedLine Citation:
PMID:  767195     Owner:  NLM     Status:  MEDLINE    
In indirect immunofluorescence tests, antibodies against pure porcine cholecystokinin (CCK) have detected specific CCK cells in the duodenal and jejunal mucosa of the dog and man. The CCK cells were scattered in the epithelium of the crypts, although some were in the villi. No CCK cells were found in the stomach, pancreas, terminal ileum, or colon. Some pyloric G cells also showed some reactivity with CCK antiserum, but absorption of CCK antiserum with gastrin C terminal pentapeptide prevented the staining of pyloric cells and provided specific staining of intestinal CCK cells. Anti-human gastrin I serum stained some intestinal cells too. Most of such cells did not react when gastrin antiserum was absorbed with pure CCK (a treatment that did not prevent the staining of pyloric gastrin cells); they were interpreted as cross-reacting CCK cells rather than as intestinal gastrin cells.
R Buffa; E Solcia; V L Go
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  70     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-05-18     Completed Date:  1976-05-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  528-32     Citation Subset:  AIM; IM    
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MeSH Terms
Cross Reactions
Duodenum / analysis,  cytology*
Epithelial Cells
Epithelium / analysis
Fluorescent Antibody Technique
Immune Sera / isolation & purification
Intestinal Mucosa / analysis,  cytology*
Iodine Radioisotopes
Jejunum / analysis,  cytology*
Pylorus / analysis,  cytology
Reg. No./Substance:
0/Immune Sera; 0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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