Document Detail

Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma.
MedLine Citation:
PMID:  22549618     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES/HYPOTHESIS: The prognosis for laryngeal squamous cell carcinoma (LSCC) has not shown any improvement in the last 30 years because of inadequate prognostic stratification. Therefore, the detection of reliable molecular markers may have a significant impact on clinical practice. As promising data regarding HER1/EGFR have been published, the purpose of the present study was to elucidate the role of the other receptors of the HER family.
STUDY DESIGN: Retrospective.
METHODS: We used quantitative immunohistochemistry to evaluate the expression pattern of the HER4 receptors cytokeratin (CK)-14, CK-17, and proliferating cell nuclear antigen in 67 LSCCs and assessed correlations with various prognostic parameters.
RESULTS: HER1 levels inversely correlated with those of HER2-4. The negative prognostic value of HER1 was confirmed, and a protective role for HER2-4 was found. Specifically, the overexpression of HER4 and its nuclear localization are protective and are associated with a better prognosis.
CONCLUSIONS: Semiquantitative evaluation of HER2-4 provides predictive information that can be combined with HER1 expression data for molecular characterization of LSCC. The pattern of localization of HER4 is an easily evaluable qualitative parameter with a clear correlation with prognosis. The immunohistochemical methods described in this article are reliable, reproducible, and potentially translatable to clinical practice.
Francesco Bussu; Franco O Ranelletti; Marco Gessi; Cristina Graziani; Paola Lanza; Libero Lauriola; Gaetano Paludetti; Giovanni Almadori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-01
Journal Detail:
Title:  The Laryngoscope     Volume:  122     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-10-05     Revised Date:  2013-06-21    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1724-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Department of Otolaryngology, Catholic University of the Sacred Heart, Rome.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology*,  therapy
Chemoradiotherapy, Adjuvant
Combined Modality Therapy
Follow-Up Studies
Head and Neck Neoplasms / pathology*,  therapy
Immunoenzyme Techniques*
Keratin-14 / analysis
Keratin-17 / analysis
Laryngeal Mucosa / pathology
Laryngeal Neoplasms / pathology*,  therapy
Larynx / pathology
Lymphatic Metastasis
Middle Aged
Neck Dissection
Neoplasm Grading
Neoplasm Staging
Proliferating Cell Nuclear Antigen / analysis
Receptor, Epidermal Growth Factor / analysis*
Sensitivity and Specificity
Reg. No./Substance:
0/Keratin-14; 0/Proliferating Cell Nuclear Antigen; EC protein, human; EC, Epidermal Growth Factor; EC tyrosine-protein kinase erbB-4

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