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Immunohistochemical expression of oncological proliferation markers in the hearts of rats during normal pregnancy.
MedLine Citation:
PMID:  23387493     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aim: Pregnancy is characterized by left ventricular hypertrophy that is potentially accounted for by cardiomyocyte proliferation, although no such evidence is currently available. This study investigates if the left ventricular mass (LVM) increase during pregnancy implies cell hyperplasia. Materials & methods: In nonpregnant and late-pregnant rats, cardiac function and LVM were evaluated by MRI, and cardiomyocyte dimensions and proliferations were assessed quantitatively by morphometric analysis and immunohistochemistry using oncological markers (Ki67 and MCM2). Results: In late-pregnant rats, LVM and cardiomyocyte area were greater. No mitotic figures were found nor was there any significant difference between groups in Ki67 expression. MCM2 expression was related to LVM. Conclusion: During pregnancy, rat cardiomyocytes undergo hypertrophy but not hyperplasia; the expression of MCM2, related to LVM, suggests it could be a marker of protein synthesis. The application of oncological markers to physiological contexts may provide insight into their role within the cell cycle.
Authors:
Michele M Ciulla; Giulia Acquistapace; Gianluca L Perrucci; Paola Nicolini; Laura Toffetti; Paola Braidotti; Stefano Ferrero; Ileana Zucca; Domenico Aquino; Giuseppe Busca; Fabio Magrini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  7     ISSN:  1752-0371     ISO Abbreviation:  Biomark Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-29     Citation Subset:  IM    
Affiliation:
Department of Clinical Science & Community Health, Laboratory of Clinical Informatics & Cardiovascular Imaging, University of Milan, 20122 Milan, Italy.
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