| Immunohistochemical expression of oncological proliferation markers in the hearts of rats during normal pregnancy. | |
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MedLine Citation:
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PMID: 23387493 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim: Pregnancy is characterized by left ventricular hypertrophy that is potentially accounted for by cardiomyocyte proliferation, although no such evidence is currently available. This study investigates if the left ventricular mass (LVM) increase during pregnancy implies cell hyperplasia. Materials & methods: In nonpregnant and late-pregnant rats, cardiac function and LVM were evaluated by MRI, and cardiomyocyte dimensions and proliferations were assessed quantitatively by morphometric analysis and immunohistochemistry using oncological markers (Ki67 and MCM2). Results: In late-pregnant rats, LVM and cardiomyocyte area were greater. No mitotic figures were found nor was there any significant difference between groups in Ki67 expression. MCM2 expression was related to LVM. Conclusion: During pregnancy, rat cardiomyocytes undergo hypertrophy but not hyperplasia; the expression of MCM2, related to LVM, suggests it could be a marker of protein synthesis. The application of oncological markers to physiological contexts may provide insight into their role within the cell cycle. |
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Authors:
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Michele M Ciulla; Giulia Acquistapace; Gianluca L Perrucci; Paola Nicolini; Laura Toffetti; Paola Braidotti; Stefano Ferrero; Ileana Zucca; Domenico Aquino; Giuseppe Busca; Fabio Magrini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomarkers in medicine Volume: 7 ISSN: 1752-0371 ISO Abbreviation: Biomark Med Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312535 Medline TA: Biomark Med Country: England |
Other Details:
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Languages: eng Pagination: 119-29 Citation Subset: IM |
Affiliation:
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Department of Clinical Science & Community Health, Laboratory of Clinical Informatics & Cardiovascular Imaging, University of Milan, 20122 Milan, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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