Document Detail


Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: correlation with symptoms and aortic diameter.
MedLine Citation:
PMID:  14612975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our purpose was to investigate the expression of matrix metalloproteinase (MMP)-2 and -9 in all types of abdominal aortic aneurysms (AAA): symptomatic, asymptomatic, and ruptured. MMP-2 and -9 activity was investigated in surgical samples from the arterior wall of 46 AAA, using a standard immunohistochemical technique. The MMP-9 activity was significantly higher in large AAA (>6 cm), but there was no relation between AAA size and MMP-2 activity. Neither MMP-2 nor MMP-9 were related with AAA rupture, other complications or symptoms. The MMP-9 activity in AAA is a determinant of the aneurysm size, but it is not related to clinical manifestations.
Authors:
Efstathios Papalambros; Fragiska Sigala; Sotiris Georgopoulos; Charalambos Menekakos; Alexandra Giatromanolaki; Elias Bastounis; Efthymios Sivridis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  12     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-12     Completed Date:  2004-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  965-8     Citation Subset:  IM    
Affiliation:
First Department of Surgery, University of Athens, 27 Chremonidou Street, 11633 Pagrati, Athens, Greece. drsigala@otenet.gr
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MeSH Terms
Descriptor/Qualifier:
Aortic Aneurysm, Abdominal / metabolism*,  physiopathology
Extracellular Matrix / metabolism
Humans
Immunohistochemistry
Matrix Metalloproteinase 2 / metabolism*
Matrix Metalloproteinase 9 / metabolism*
Chemical
Reg. No./Substance:
EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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