| Immunohistochemical expression of atrial natriuretic peptide (ANP) in the conducting system and internodal atrial myocardium of human hearts. | |
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MedLine Citation:
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PMID: 9248576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Expression and distribution of atrial natriuretic peptide (ANP) were studied immunohistochemically in the conducting system and internodal atrial myocardium of 5 adult human hearts. Myocytes from the sinus node and compact atrioventricular node were usually ANP-negative; only a very few cells exhibited ANP immunoreactivity. These ANP-positive myocytes were small and did not appear to be trapped working atrial myocytes which are larger than nodal cells. The transitional cell zones of the sinus node and the atrioventricular node were composed of bundles of ANP-positive myocytes, intermingled with non-reactive myocytes. The internodal atrial myocardium exhibited a comparable intensity of myocyte staining in each case examined. Thus, morphologically distinct connecting pathways between the sinus node and the atrioventricular node with regard to myocyte ANP immunoreactivity could not be demonstrated, reinforcing the notion that they actually do not exist. The penetrating bundle, branching bundle and bundle branches were usually composed of ANP-negative myocytes although some ANP-positive myocytes were observed in the branching bundle and bundle branches in 4 cases. Myocytes from the ventricular conducting tissue presenting ANP immunoreactivity have been designated Purkinje fibers and have been found in several mammalian species. |
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Authors:
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L A Benvenuti; V D Aiello; M de L Higuchi; S A Palomino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta histochemica Volume: 99 ISSN: 0065-1281 ISO Abbreviation: Acta Histochem. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-09-05 Completed Date: 1997-09-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370320 Medline TA: Acta Histochem Country: GERMANY |
Other Details:
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Languages: eng Pagination: 187-93 Citation Subset: IM |
Affiliation:
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Department of Pathology, São Paulo University Medical School, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrial Natriuretic Factor / chemistry* Atrioventricular Node / chemistry, cytology, immunology Female Heart Atria / chemistry, cytology, immunology Heart Conduction System / chemistry* Humans Immunohistochemistry Male Middle Aged Myocardium / chemistry*, cytology*, immunology Sinoatrial Node / chemistry, cytology, immunology |
| Chemical | |
Reg. No./Substance:
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85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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