Document Detail

Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy.
MedLine Citation:
PMID:  16704492     Owner:  NLM     Status:  MEDLINE    
Bestatin, a specific inhibitor of aminopeptidase N (CD13), has been reported to prolong survival time in patients with completely resected stage I lung squamous cell carcinoma. Considering the antitumor mechanism of Bestatin, it is interesting to know whether CD13 is expressed in human lung squamous cell carcinoma. The immunohistochemical expression of CD13 was examined in human lung carcinoma and the question of whether CD13 was immunohistochemically expressed in the interstitial tissue was investigated, mainly in the fibroblasts and blood vessels, surrounding the tumor nests of various kinds of non-small cell lung cancers, especially of squamous cell carcinomas. In Japanese squamous cell carcinoma of the lung, 38 (61.3%) out of 62 cancers were positively stained in the same manner on immunohistochemistry for CD13. The area of interstitial tissue positively stained for CD13 varied depending on the case. To confirm the cell nature of the interstitial tissue with CD13 positivity, double immunohistochemistry using CD34 and alpha-smooth muscle actin was performed. Double immunohistochemistry showed that the majority of CD13-positive cells were slender fibroblastic cells around the blood vessels and some endothelial cells.
Eiji Ichimura; Masatoshi Yamada; Kiyohiro Nishikawa; Fuminori Abe; Takashi Nakajima
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  56     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-17     Completed Date:  2006-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  296-300     Citation Subset:  IM    
R&D Division, Nippon Kayaku, Tokyo, Japan.
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MeSH Terms
Adjuvants, Immunologic / therapeutic use*
Aged, 80 and over
Antigens, CD13 / antagonists & inhibitors,  metabolism*
Carcinoma, Squamous Cell / drug therapy,  enzymology*,  pathology
Fluorescent Antibody Technique, Indirect
Immunoenzyme Techniques
Leucine / analogs & derivatives*,  therapeutic use
Lung Neoplasms / drug therapy,  enzymology*,  pathology
Middle Aged
Tissue Array Analysis
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Tumor Markers, Biological; 58970-76-6/bestatin; 61-90-5/Leucine; EC, CD13

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