| Immunohistochemical evaluation of substance P and calcitonin gene-related peptide in skin and periosteum after extracorporeal shock wave therapy and radial pressure wave therapy in sheep. | |
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MedLine Citation:
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PMID: 17331023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of focused extracorporeal shock wave therapy (ESWT) and radial pressure wave therapy (RPWT) on immunohistochemical staining for substance P and calcitonin gene-related peptide (CGRP) in the skin and periosteum of sheep. ANIMALS: 36 sheep. PROCEDURES: All 4 limbs of 36 sheep were treated with ESWT, RPWT, or a sham treatment. For 14 days after treatment, at least 2 sheep were euthanized daily and tissue was harvested for histologic evaluation of nerves via staining for substance P and CGRP in the skin and periosteum. RESULTS: No effects of ESWT or RPWT were observed on the number of nerves with stain uptake for substance P or CGRP in the skin or periosteum. CONCLUSIONS AND CLINICAL RELEVANCE: Substance P- and CGRP-containing nerve fibers are not disrupted by EWST or RPWT. Further studies are needed to identify the mechanism of analgesia observed in association with these treatment modalities. |
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Authors:
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Janan M Abed; Scott R McClure; Michael J Yaeger; Richard B Evans |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of veterinary research Volume: 68 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-02 Completed Date: 2007-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: United States |
Other Details:
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Languages: eng Pagination: 323-8 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia
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methods,
veterinary Animals Calcitonin Gene-Related Peptide / analysis*, metabolism High-Energy Shock Waves / adverse effects*, therapeutic use* Immunohistochemistry / veterinary Neurons / metabolism Periosteum / metabolism* Pressure Sheep / physiology* Skin / metabolism* Substance P / analysis*, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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