Document Detail

Immunohistochemical evaluation of PCNA and Ki-67 in ameloblastoma.
MedLine Citation:
PMID:  11167148     Owner:  NLM     Status:  MEDLINE    
Thirty-two ameloblastoma tissues were immunohistochemically studied using monoclonal anti-proliferating cell nuclear antigen (PCNA) and anti-Ki-67 antibodies. Positive cells were evaluated and analyzed in relation to the WHO classification, cytological pattern of the outer layer cell, clinical appearance, tumor location, radiographic appearance and patient's age. In regard to the cytological pattern of the outer layer cells, the basal cell type had significantly higher PCNA and Ki-67 (P<0.05) labeling indices than the cuboidal cell type. The solid type had significantly higher PCNA and Ki-67 (P<0.05) labeling indices than the cystic and the mixed type. The labeling index of the younger patient was found to be the lowest, the middle age was in the middle and the older patient was the highest. These results indicated that the proliferating activities of ameloblastomas are quite variable, and the evaluations of Ki-67 and PCNA seem to be good indicators to assess the proliferating activity of each type of ameloblastomas.
F Sandra; T Mitsuyasu; N Nakamura; Y Shiratsuchi; M Ohishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral oncology     Volume:  37     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
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MeSH Terms
Age Factors
Aged, 80 and over
Ameloblastoma / chemistry*,  pathology
Cell Division
Ki-67 Antigen / analysis*
Mandibular Neoplasms / chemistry*,  pathology
Maxillary Neoplasms / chemistry*,  pathology
Middle Aged
Neoplasms, Basal Cell / chemistry,  pathology
Neoplasms, Complex and Mixed / chemistry,  pathology
Proliferating Cell Nuclear Antigen / analysis*
Reg. No./Substance:
0/Ki-67 Antigen; 0/Proliferating Cell Nuclear Antigen

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