Document Detail


Immunohistochemical distribution of basic fibroblast growth factor (bFGF) in medicolegal autopsy.
MedLine Citation:
PMID:  19261517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Basic fibroblast growth factor (bFGF) is a highly conserved and ubiquitously distributed mitogen, and much is known at the molecular level. However the available information about in vivo distribution in human tissues and expression changes in relation to causes of death is not sufficient. The present study investigated 35 autopsy cases, comprising five cases for each cause of death: acute myocardial infarction/ischemia (AMI), mechanical asphyxiation, blunt brain injury, drowning, hypothermia, intoxication and sharp instrument injury. The bFGF immunopositivity was detected mainly in interstitial cells and sporadically in cardiomyocytes in the heart, in macrophages in the lung, astrocytes in the brain, mainly in the sinusoidal Kupffer cells and partly in the hepatocytes in the liver, red pulp of the spleen, pancreatic islets and proximal convoluted tubules and corpuscles in the kidney. Immunopositivity was frequently detected in the lung and liver for AMI and hypothermia, and in the kidney for AMI, mechanical asphyxiation, drowning and injuries, but was not evident in the kidney for hypothermia. Positivity in these tissues varied by case in other causes of death. High positivity in the brain was seen for intoxication, but AMI, mechanical asphyxiation and drowning showed lower positivity. For the heart, spleen and pancreas, there was no evident difference among the causes of death. These findings suggested that bFGF expression in the lung, liver, kidney and brain varies depending on the cause of death, and is useful for investigating deaths.
Authors:
Qi Wang; Takaki Ishikawa; Li Quan; Dong Zhao; Dong-Ri Li; Tomomi Michiue; Jian-Hua Chen; Bao-Li Zhu; Hitoshi Maeda
Related Documents :
15242837 - Saturation of high-frequency oscillations of r-r intervals in healthy subjects and pati...
15892017 - Comparison between human and automated electrocardiographic waveform measurements for c...
12906367 - Hypothalamo-pituitary-adrenal axis in acute myocardial infarction treated by percutaneo...
12767547 - Electrocardiographic prediction of the development and site of acute myocardial infarct...
21078527 - Immune responses after acute ischemic stroke or myocardial infarction.
18599547 - Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sym...
Publication Detail:
Type:  Journal Article     Date:  2009-03-03
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  11 Suppl 1     ISSN:  1873-4162     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S161-4     Citation Subset:  IM    
Affiliation:
Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585 Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asphyxia / metabolism
Astrocytes / metabolism
Brain / cytology,  metabolism
Brain Injuries / metabolism
Drowning / metabolism
Female
Fibroblast Growth Factor 2 / metabolism*
Forensic Pathology
Hepatocytes / metabolism
Humans
Hypothermia / metabolism
Immunohistochemistry
Islets of Langerhans / metabolism
Kidney / metabolism
Kupffer Cells / metabolism
Macrophages, Alveolar / metabolism
Male
Middle Aged
Myocardial Infarction / metabolism
Myocytes, Cardiac / metabolism
Poisoning / metabolism
Spleen / metabolism
Wounds, Stab / metabolism
Chemical
Reg. No./Substance:
103107-01-3/Fibroblast Growth Factor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Haplotypes in the 5'-upstream region, exons 3 and 4, and introns 2 and 3 of the ABO blood group gene...
Next Document:  The interaction of the international society concerning kidney transplants--a consideration of disea...