Document Detail

Immunohistochemical distribution of basic fibroblast growth factor (bFGF) in medicolegal autopsy.
MedLine Citation:
PMID:  19261517     Owner:  NLM     Status:  MEDLINE    
Basic fibroblast growth factor (bFGF) is a highly conserved and ubiquitously distributed mitogen, and much is known at the molecular level. However the available information about in vivo distribution in human tissues and expression changes in relation to causes of death is not sufficient. The present study investigated 35 autopsy cases, comprising five cases for each cause of death: acute myocardial infarction/ischemia (AMI), mechanical asphyxiation, blunt brain injury, drowning, hypothermia, intoxication and sharp instrument injury. The bFGF immunopositivity was detected mainly in interstitial cells and sporadically in cardiomyocytes in the heart, in macrophages in the lung, astrocytes in the brain, mainly in the sinusoidal Kupffer cells and partly in the hepatocytes in the liver, red pulp of the spleen, pancreatic islets and proximal convoluted tubules and corpuscles in the kidney. Immunopositivity was frequently detected in the lung and liver for AMI and hypothermia, and in the kidney for AMI, mechanical asphyxiation, drowning and injuries, but was not evident in the kidney for hypothermia. Positivity in these tissues varied by case in other causes of death. High positivity in the brain was seen for intoxication, but AMI, mechanical asphyxiation and drowning showed lower positivity. For the heart, spleen and pancreas, there was no evident difference among the causes of death. These findings suggested that bFGF expression in the lung, liver, kidney and brain varies depending on the cause of death, and is useful for investigating deaths.
Qi Wang; Takaki Ishikawa; Li Quan; Dong Zhao; Dong-Ri Li; Tomomi Michiue; Jian-Hua Chen; Bao-Li Zhu; Hitoshi Maeda
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Publication Detail:
Type:  Journal Article     Date:  2009-03-03
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  11 Suppl 1     ISSN:  1873-4162     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S161-4     Citation Subset:  IM    
Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585 Osaka, Japan.
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MeSH Terms
Asphyxia / metabolism
Astrocytes / metabolism
Brain / cytology,  metabolism
Brain Injuries / metabolism
Drowning / metabolism
Fibroblast Growth Factor 2 / metabolism*
Forensic Pathology
Hepatocytes / metabolism
Hypothermia / metabolism
Islets of Langerhans / metabolism
Kidney / metabolism
Kupffer Cells / metabolism
Macrophages, Alveolar / metabolism
Middle Aged
Myocardial Infarction / metabolism
Myocytes, Cardiac / metabolism
Poisoning / metabolism
Spleen / metabolism
Wounds, Stab / metabolism
Reg. No./Substance:
103107-01-3/Fibroblast Growth Factor 2

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