| Immunohistochemical distribution of S-100 protein and glial fibrillary acidic protein in normal and neoplastic salivary glands. | |
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MedLine Citation:
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PMID: 2983489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunohistochemical localization of S-100 protein, its alpha and beta subunits, and glial fibrillary acidic protein (GFAP) in normal and neoplastic salivary glands was studied by the peroxidase-antiperoxidase method and immunoblot analysis. Positive immunostaining for S-100 protein was observed in pleomorphic adenoma, adenolymphoma, tubular adenoma, adenoid cystic carcinoma, acinic cell tumour, adenocarcinoma and carcinoma in pleomorphic adenoma. S-100 protein was localized in myoepithelial cells, epithelial cells of intercalated ducts and serous acinar cells of normal salivary gland. Both alpha and beta subunits of S-100 protein showed almost identical distribution in normal and neoplastic salivary glands, but skeletal muscle cells were alpha-positive/beta-negative whereas Schwann cells and fat cells were alpha-negative/beta-positive in the stroma and neighbouring tissue. GFAP was only found in pleomorphic adenoma and its malignant counterpart. Immunoblot analysis showed that the GFAP-related antigen consisted of several polypeptide bands with a molecular weight ranging between 35,000 to 50,000 daltons. |
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Authors:
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Y Nakazato; Y Ishida; K Takahashi; K Suzuki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Virchows Archiv. A, Pathological anatomy and histopathology Volume: 405 ISSN: 0174-7398 ISO Abbreviation: Virchows Arch A Pathol Anat Histopathol Publication Date: 1985 |
Date Detail:
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Created Date: 1985-04-18 Completed Date: 1985-04-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302198 Medline TA: Virchows Arch A Pathol Anat Histopathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 299-310 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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analysis Adenoma, Pleomorphic / analysis Antigens / analysis* Antigens, Neoplasm / analysis Carcinoma, Adenoid Cystic / analysis Epithelium / analysis Glial Fibrillary Acidic Protein / analysis* Histocytochemistry Humans Immunoenzyme Techniques Parotid Neoplasms / analysis Peptide Fragments / analysis S100 Proteins / analysis* Salivary Gland Neoplasms / analysis*, immunology Salivary Glands / analysis*, cytology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antigens, Neoplasm; 0/Glial Fibrillary Acidic Protein; 0/Peptide Fragments; 0/S100 Proteins |
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