Document Detail

Immunohistochemical diagnosis of pulmonary eosinophilic granuloma on lung biopsy.
MedLine Citation:
PMID:  2461275     Owner:  NLM     Status:  MEDLINE    
S-100 protein immunostaining has been advocated to identify the characteristic Langerhans' cells in the histologic diagnosis of PEG. Reliable demonstration of an increased number of Langerhans' cells is essential in difficult biopsy cases, since occasional Langerhans' cells can be found in other pulmonary lesions. We examined the S-100 protein labeling pattern in three cases of PEG and in a variety of controls. Non-Langerhans' histiocytes were labeled for lysozyme antigen on the same histologic sections using a combined ABC and PAP technique. This verified that the S-100 protein-negative histiocytes were indeed a separate population from the S-100 protein-positive histiocytes and did not represent Langerhans' cells which failed to label with antiserum to S-100 protein. This technique confirms the usefulness of S-100 protein staining in the diagnosis of PEG and offers a means to verify the reliability of the S-100 protein labeling in questionable cases.
P T Cagle; C A Mattioli; L D Truong; S D Greenberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  94     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-12     Completed Date:  1989-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1133-7     Citation Subset:  AIM; IM    
Department of Pathology, Baylor College of Medicine, Houston.
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MeSH Terms
Eosinophilic Granuloma / diagnosis*,  pathology
Granulocytes / pathology
Histiocytes / pathology
Langerhans Cells / pathology
Lung / pathology
Lung Diseases / diagnosis*,  pathology
Muramidase / diagnostic use
S100 Proteins / diagnostic use
Staining and Labeling
Reg. No./Substance:
0/S100 Proteins; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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