Document Detail

Immunohistochemical detection of p27 and p21 proteins in canine hair follicle and epidermal neoplasms.
MedLine Citation:
PMID:  16953075     Owner:  NLM     Status:  MEDLINE    
Trichoblastomas, trichoepitheliomas, and squamous cell carcinomas in the skin of dogs were analysed by immunohistochemistry for the nuclear expression of p27, p21 and proliferating cell nuclear antigen (PCNA). High levels of p27 were present in trichoepitheliomas and trichoblastomas compared with squamous cell carcinomas. Detectable p21 was found in trichoepitheliomas and squamous cell carcinomas, but trichoblastomas had low level of p21 nuclear reactivity. Low levels of PCNA were detected in trichoepitheliomas and trichoblastomas compared with squamous cell carcinomas. The results suggested that nuclear p27 acts as a cyclin-dependent kinase (CDK) inhibitor in trichoepitheliomas and trichoblastomas. Nuclear p21 expression is involved in the induction of epithelial differentiation and seems to be unrelated to CDK inhibition.
Makoto Inoue; Haiyan Wu; Satoshi Une
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  68     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-09-05     Completed Date:  2006-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  779-82     Citation Subset:  IM    
Department of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan.
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MeSH Terms
Cyclin-Dependent Kinase Inhibitor p21 / metabolism*
Dog Diseases / metabolism
Epidermis / metabolism*,  pathology
Gene Expression Regulation, Neoplastic
Hair Follicle / metabolism*,  pathology
Immunohistochemistry / methods,  veterinary*
Proliferating Cell Nuclear Antigen / metabolism*
Skin Neoplasms / metabolism*,  pathology
Reg. No./Substance:
0/Cyclin-Dependent Kinase Inhibitor p21; 0/Proliferating Cell Nuclear Antigen; 0/p27 antigen

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