| Immunohistochemical detection of mutant p53 protein in regional lymph nodes is associated with adverse outcome in stage II colorectal cancer. | |
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MedLine Citation:
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PMID: 10682269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiologic data identifies a cohort of Duke's B (CRC) patients whose survival more closely matches that of Duke's C. Lymph node micrometastases may account for this discrepancy. Lymph node expression of mutant p53 protein (Mp53P) has been linked to a reduction in survival in Japanese Duke's B patients. We aimed to determine the significance of nodal p53 expression in European Duke's B patients using immunohistochemistry. The study comprised 134 consecutive patients who had resections for CRC between 1984 and 1991. End points were 5 year disease free survival or CRC related death. Thirty-four subjects did not achieve end points and were excluded. We examined tumour and nodal sections for Mp53P by immunohistochemistry and correlated this with survival using a Kaplan-Meier (KM) and a Cox Proportional hazards model (CPHT). Five year survival was 73%. Fifty-eight percent of primary tumours expressed Mp53P. Tumour p53 expression did modulate survival behavior. Twenty-six percent of subjects' lymph nodes expressed Mp53P. Fifty-three per cent of those with positive and 17% of those with negative lymph nodes died of recurrence. The relative risk for nodal Mp53P expression was 3.1. There was a significant univariate relationship between lymph node p53 expression and mortality. (Log Rank p = 0.028). Multivariate analysis also showed a significant relationship with mortality. (CPHT p = .03). We conclude that lymph node expression of Mp53P is associated with increased mortality in Duke's B CRC. |
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Authors:
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G Clarke; E Ryan; J Crowe; J C O'Keane; P MacMathúna |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of histochemistry : EJH Volume: 43 ISSN: 1121-760X ISO Abbreviation: Eur J Histochem Publication Date: 1999 |
Date Detail:
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Created Date: 2000-03-22 Completed Date: 2000-03-22 Revised Date: 2008-08-15 |
Medline Journal Info:
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Nlm Unique ID: 9207930 Medline TA: Eur J Histochem Country: ITALY |
Other Details:
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Languages: eng Pagination: 311-6 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Mater Misericordiae Hospital, Dublin, Ireland. gclarke@rics.bwh.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Colorectal Neoplasms / chemistry*, genetics, mortality*, pathology Humans Immunohistochemistry Lymph Nodes / chemistry*, pathology Middle Aged Multivariate Analysis Mutation* Neoplasm Staging Prognosis Survival Analysis Tumor Suppressor Protein p53 / analysis*, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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