| Immunohistochemical detection of lactoferrin in human astrocytomas and multiforme glioblastomas. | |
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MedLine Citation:
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PMID: 10682270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The presence of lactoferrin in astrocytomas, anaplastic astrocytomas and multiforme glioblastomas was determined by immunohistochemistry; the staining intensity and the percentage of neoplastic stained cells were graded and statistical analysis was performed by non-parametric methods. A moderate to strong diffuse immunoreactivity for lactoferrin was shown in glial elements of astrocytomas, while the positivity was progressively reduced in anaplastic astrocytomas and in multiforme glioblastomas, some of which were unstained; a highly significant difference was found between scores relative to astrocytomas and glioblastomas. We suggest that the lactoferrin may be produced by neoplastic astrocytes which permits a greater availability of iron for metabolic cellular processes. Alternatively, the cytoplasmic localization of lactoferrin in neoplastic astrocytes may be the consequence of defective or functionally impaired lactoferrin receptors at the cellular surface. |
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Authors:
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G Tuccari; G Giuffrè; C Crisafulli; G Barresi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of histochemistry : EJH Volume: 43 ISSN: 1121-760X ISO Abbreviation: Eur J Histochem Publication Date: 1999 |
Date Detail:
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Created Date: 2000-03-22 Completed Date: 2000-03-22 Revised Date: 2008-08-15 |
Medline Journal Info:
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Nlm Unique ID: 9207930 Medline TA: Eur J Histochem Country: ITALY |
Other Details:
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Languages: eng Pagination: 317-22 Citation Subset: IM |
Affiliation:
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Dept. of Human Pathology, University of Messina, Italy. tuccari@imeuniv.unime.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Astrocytoma
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chemistry*,
pathology Brain Neoplasms / chemistry*, pathology Female Glioblastoma / chemistry*, pathology Humans Immunohistochemistry Iron / analysis Lactoferrin / analysis* Male Middle Aged Staining and Labeling / methods |
| Chemical | |
Reg. No./Substance:
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0/Lactoferrin; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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