Document Detail


Immunohistochemical detection of changes in growth hormone cells in rat pituitaries in protein deficiency.
MedLine Citation:
PMID:  46755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. An immunohistochemical method was used to study the effect of a low-protein diet on growth hormone (GH) cells in the pituitaries of developing rats. The deficient diet (80 g protein/kg) was administered during gestation and lactation, or during the time after weaning until 90 d of age, or during both periods. 2. GH-cell changes were much more striking in males than in females. 3. In males, GH-producing cells were usually reduced in size and number in all treatments. The effect was most intense when protein deprivation occurred throughout gestation and sucking, and continued until 90 d of age, but it was also evident in animals given the low-protein diet only after weaning. Recuperation appeared to be almost complete when offspring of deprived dams were fed on a normal diet after weaning. 4. It is concluded that a low-protein diet reduces the amount of GH in the rat pituitary in a way similar to that with a protein-free diet.
Authors:
T Drummond
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  33     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-06-02     Completed Date:  1975-06-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies
Female
Growth Hormone / biosynthesis*
Histocytochemistry
Immunochemistry
Lactation
Male
Pituitary Gland / cytology*,  immunology
Pregnancy
Protein Deficiency / immunology,  metabolism*
Rats
Sex Factors
Staining and Labeling
Chemical
Reg. No./Substance:
0/Antibodies; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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