Document Detail


Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis.
MedLine Citation:
PMID:  11209133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transgenic mice overexpressing hepatocyte growth factor/scatter factor (HGF/SF) demonstrate extensive pigmented nevi in both skin and leptomeninges of the central nervous system resembling human neurocutaneous melanosis. We immunohistochemically detected HGF/SF receptor, Met, in a congenital nevus of an infant with neurocutaneous melanosis, indicating that deregulation of HGF/SF-Met signaling in the critical period of development may lead to this fatal syndrome.
Authors:
H Takayama; Y Nagashima; M Hara; H Takagi; M Mori; G Merlino; Y Nakazato
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  44     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-21     Completed Date:  2001-04-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  538-40     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan. hitakaya@showa.gunma-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Child, Preschool
Humans
Immunohistochemistry
Male
Melanosis / genetics*,  immunology
Mice
Neurocutaneous Syndromes / genetics*,  immunology
Nevus, Pigmented / congenital*,  immunology,  pathology
Proto-Oncogene Proteins c-met / analysis*,  immunology
Signal Transduction
Chemical
Reg. No./Substance:
EC 2.7.10.1/Proto-Oncogene Proteins c-met

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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