| Immunohistochemical detection of arteriolar hyperplasia in canine liver biopsy samples using the claudin-5 antibody. | |
| | |
MedLine Citation:
|
PMID: 21087912 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Claudins are key tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, which are responsible for the permeability of the paracellular space. This paper describes that the endothelial cells of normal hepatic arterioles, portal venules and portal lymphatics as well as the endothelium of sinusoids from dogs show strong membranous claudin-5 cross-reactivity. In 25 liver biopsy samples taken from dogs with portal vein hypoperfusion, an increased number of arterioles was detected in the portal areas (PAs) by the use of humanised anti-claudin-5 antibody. The increased number of hyperplastic hepatic arterioles per PA was 5-6, 8-12 and 15-20 in the case of small, medium-sized and large PAs, respectively. It is suggested that the claudin-5 marker can improve the detection of hepatic arteriolar proliferation in the PAs of liver samples. |
| | |
Authors:
|
Csaba Jakab; Miklós Rusvai; Péter Gálfi; Agnes Szabára; Zoltán Szabó; Janina Kulka |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta veterinaria Hungarica Volume: 58 ISSN: 0236-6290 ISO Abbreviation: Acta Vet. Hung. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8406376 Medline TA: Acta Vet Hung Country: Hungary |
Other Details:
|
Languages: eng Pagination: 423-30 Citation Subset: IM |
Affiliation:
|
Department of Pathology and Forensic Veterinary Medicine, István u. 2 H-1078 Budapest, Hungary. Jakab.Csaba@aotk.szie.hu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vertebral osteomyelitis and meningomyelitis caused by Pasteurella canis in a dog--clinicopathologica...
Next Document: In situ complex adenocarcinoma on the femoral part of the hindlimb in an Asian Leaf Turtle (Cyclemys...