Document Detail

Immunohistochemical demonstration of spread of Aujeszky's disease virus to the porcine central nervous system after intestinal inoculation.
MedLine Citation:
PMID:  9651809     Owner:  NLM     Status:  MEDLINE    
Aujeszky's disease virus (ADV) was injected into the duodenal lumen of eight specific pathogen-free pigs aged 5 weeks. The infected pigs did not show any diarrhoea or nervous symptoms, but they developed characteristic necrotizing enteritis and myenteric plexitis, accompanied by follicular necrosis in the Peyer's patches. ADV antigen was detected in the submucosa of the dome area of Peyer's patches, lymphatic follicles, Meissner's and Auerbach's plexuses, solar ganglia and thoracic spinal ganglia. These findings suggest that ADV spreads from the intestinal mucosa to the central nervous system via the autonomic nerves.
M Narita; K Kimura; N Tanimura; S Arai; A Uchimura
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  118     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-15     Completed Date:  1998-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-36     Citation Subset:  IM    
National Institute of Animal Health, Ministry of Agriculture, Forestry and Fisheries, Ibaraki, Japan.
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MeSH Terms
Antigens, Viral / analysis
Central Nervous System Diseases / pathology,  virology*
Enteric Nervous System / virology*
Herpesviridae / immunology,  isolation & purification,  pathogenicity*
Inclusion Bodies, Viral / pathology,  virology
Intestinal Mucosa / pathology,  virology*
Pseudorabies / pathology,  virology*
Swine Diseases / pathology,  virology*
Reg. No./Substance:
0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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