| Immunohistochemical co-localization of placental lactogen II and relaxin in the golden hamster (Mesocricetus auratus). | |
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MedLine Citation:
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PMID: 2355175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two hormones with lactogenic activity are produced by the hamster placenta during the second half of pregnancy. One of these hormones, hamster placental lactogen II (haPL-II), has been well characterized; however, its cellular source is not known. In the present study, haPL-II was localized in placental tissues using a specific antibody and the avidin-biotin-peroxidase immunohistochemical technique. Because relaxin has been localized in the hamster placenta, it was of interest to determine if haPL-II and relaxin are localized in the same cells. haPL-II immunoactivity was observed in primary and secondary giant trophoblast cells of the placenta on Days 12, 14, and 15 of pregnancy. On Day 15 positive staining was also observed in large cells located within mesometrial arteries and in eosinophilic bodies associated with degenerating sheathed arteries of the decidua basalis. haPL-II-positive staining was not observed in placentae from Days 8 or 10 of pregnancy. On Day 14, haPL-II was colocalized with relaxin in 75% of the giant trophoblast cells observed. Therefore, it is probable that these hormones are synthesized and secreted by the same cell. |
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Authors:
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R H Renegar; J N Southard; F Talamantes |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Volume: 38 ISSN: 0022-1554 ISO Abbreviation: J. Histochem. Cytochem. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-07-25 Completed Date: 1990-07-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9815334 Medline TA: J Histochem Cytochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 935-40 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, School of Medicine, East Carolina University, Greenville, North Carolina 27858. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cricetinae Female Immunohistochemistry / methods Mesocricetus Placenta / cytology, metabolism* Placental Lactogen / metabolism* Pregnancy Relaxin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HD-14966/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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9002-69-1/Relaxin; 9035-54-5/Placental Lactogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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