| Immunohistochemical assessment of the tumour-associated epitopes CD44v6 and E48 in tumour-free lymph nodes from patients with squamous cell carcinoma in the head-neck region. | |
| | |
MedLine Citation:
|
PMID: 11153607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined immunohistochemically 370 tumour-free lymph nodes from 41 patients with a head and neck squamous cell carcinoma (HNSCC) to clarify whether the tumour-associated epitopes CD44v6 and E48 are suitable for adjuvant postoperative immunotherapy. All the positively immunostained cells found were single cells. CD44v6+ cells were found in 55% of the lymph nodes, with their numbers increasing in pN>0-patients (62%). Only pN>0-patients had abundant to massive CD44v6+ cells. A comparison with mononuclear cells in lymphatic tissue from control patients suggested a similarity with activated T-cells. In the 41 cancer patients there were significantly fewer lymph nodes with E48+ cells (11%), but the number of E48+ cells increased in pN> 1-patients (29%) with predominantly abundant E48+ cells. We conclude from the comparison with the epithelial marker EMA that the E48+ single cells are epithelial in origin. Only a specific E48 peptide sequence appears suitable for adjuvant immunotherapy in patients with head-neck tumours. |
| | |
Authors:
|
E M Fabricius; M Guschmann; A Langford; B Hell; J Bier |
Related Documents
:
|
11903597 - Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases,... 9630847 - Modification of cell cycle and viability of tlx5 lymphoma in vitro by sulfoxide-rutheni... 8220977 - The detection and modification of the hypoxic fraction in quiescent cell populations in... 15061707 - The relationship of proliferating cell density at the invasive tumour front with progno... 10581167 - Oxalate-induced and cell-cycle-dependent expression of nuclear pore complex oxalate bin... 8910197 - Properties of the camp-activated c1- current in choroid plexus epithelial cells isolate... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology Volume: 20 ISSN: 0921-8912 ISO Abbreviation: Anal Cell Pathol Publication Date: 2000 |
Date Detail:
|
Created Date: 2001-01-10 Completed Date: 2001-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8911016 Medline TA: Anal Cell Pathol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 115-29 Citation Subset: IM |
Affiliation:
|
Clinic for Maxillofacial Surgery, Medical Faculty of the Humboldt University of Berlin, Charité, Germany. eva-maria.fabricius@charite.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antigens, CD44 / analysis* Antigens, Neoplasm / analysis Carcinoma, Squamous Cell / immunology*, pathology Cell Adhesion Molecules / analysis* Epithelial Cells / immunology Epitopes / analysis Female Glycoproteins / analysis* Head and Neck Neoplasms / immunology*, pathology Humans Immunohistochemistry Lymph Nodes / immunology Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD44; 0/Antigens, Neoplasm; 0/Cell Adhesion Molecules; 0/Epitopes; 0/Glycoproteins; 0/LY6D protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Success and safety of sputum induction in the clinical setting.
Next Document: Increased cell proliferation in chronic Helicobacter pylori positive gastritis and gastric carcinoma...