Document Detail


Immunohistochemical assessment of Ki-67 as prognostic cellular proliferation marker in anal canal carcinoma.
MedLine Citation:
PMID:  11277325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to define new prognostic factors useful for therapeutic decision-making, the Authors conducted a study on anal canal carcinomas in which Ki-67 proliferation index is correlated with pathological variables and clinical outcome. The Ki-67-detectable antigen is expressed in all stages of the cells cycle except G0. Thus, Ki-67 index can measure cell proliferation and it could be considered an indicator of prognosis. Thirty-one patients with anal canal carcinoma were evaluated. The specimens were formalin-fixed, paraffin-embedded and used for immunostaining of Ki-67 antigen. We found a significant correlation between Ki-67 score and depth of invasion and lymph node involvement. No correlation was found between high Ki-67 value and neoplastic relapse. These results suggest that Ki-67 positivity carries different significance in different cancers. Additional studies are required to ascertain whether more aggressive therapeutic procedures should be applied in the subset of patients with a high growth fraction.
Authors:
M Indinnimeo; C Cicchini; A Stazi; M R Limiti; C Ghini; P Mingazzini; A Vecchione
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of experimental & clinical cancer research : CR     Volume:  19     ISSN:  0392-9078     ISO Abbreviation:  J. Exp. Clin. Cancer Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-03-29     Completed Date:  2001-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308647     Medline TA:  J Exp Clin Cancer Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  471-5     Citation Subset:  IM    
Affiliation:
Dept. of Surgery Pietro Valdoni, University of Rome La Sapienza, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anus Neoplasms / pathology*,  surgery*
Cell Division
Disease-Free Survival
Female
Humans
Immunohistochemistry
Ki-67 Antigen / analysis*
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Predictive Value of Tests
Prognosis
Recurrence
Retrospective Studies
Chemical
Reg. No./Substance:
0/Ki-67 Antigen

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