| Immunohistochemical analysis of nm23-H1 protein in bladder cancer. | |
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MedLine Citation:
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PMID: 10418173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The nm23 gene was first identified from murine K-1735 melanoma cell lines and possesses metastasis-suppressor activity. However, conflicting results concerning the metastasis-suppressor activity of nm23-H1 gene product have been reported in human solid tumors. The significance of nm23-H1 protein in bladder cancer remains to be determined. Therefore, we examined nm23-H1 protein expression immunohistochemically in bladder cancer. METHODS: Formalin-fixed, paraffin-embedded tissue specimens were obtained from 39 patients with primary bladder cancer who had undergone radical cystectomy between 1987 and 1994. The specimens were examined immunohistochemically using a monoclonal antibody to nm23-H1, and the results of immunostaining were compared with clinicopathologic factors and patient survival. RESULTS: Positive nm23-H1 protein expression was confined primarily to the cytoplasm of bladder cancer cells. A higher frequency of nm23-H1 positive expression was seen in higher stage tumors. There was a positive trend for the expression of nm23-H1 protein with the progression of the tumor (p < 0.025). No relationship was found between nm23-H1 protein expression and patients' clinicopathologic factors including age, tumor size, tumor morphology and tumor grade. Furthermore, nm23-H1 protein expression was not correlated with patient survival. CONCLUSIONS: These results suggest that in bladder cancer nm23-H1 protein expression may play an important role in tumor progression rather than in metastasis suppression. |
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Authors:
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J Y Kuo; H Chiang; K K Chen; L S Chang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zhonghua yi xue za zhi = Chinese medical journal; Free China ed Volume: 62 ISSN: 0578-1337 ISO Abbreviation: Zhonghua Yi Xue Za Zhi (Taipei) Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-05 Completed Date: 1999-08-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0005327 Medline TA: Zhonghua Yi Xue Za Zhi (Taipei) Country: CHINA |
Other Details:
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Languages: eng Pagination: 411-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, Veterans General Hospital-Taipei, Taiwan, ROC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Immunohistochemistry Male Middle Aged Monomeric GTP-Binding Proteins* NM23 Nucleoside Diphosphate Kinases Nucleoside-Diphosphate Kinase* Transcription Factors / analysis*, genetics, immunology Urinary Bladder Neoplasms / chemistry*, mortality, pathology |
| Chemical | |
Reg. No./Substance:
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0/NM23 Nucleoside Diphosphate Kinases; 0/Transcription Factors; EC 2.7.4.6/NME1 protein, human; EC 2.7.4.6/Nucleoside-Diphosphate Kinase; EC 3.6.5.2/Monomeric GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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