Document Detail

Immunohistochemical analysis of keratin distribution in eccrine poroma.
MedLine Citation:
PMID:  7678719     Owner:  NLM     Status:  MEDLINE    
Although eccrine poroma has been thought of as a neoplasm of the intradermal eccrine duct, this interpretation has not been entirely confirmed. In this study, twenty-five cases of eccrine poroma were retrieved and analyzed by immunohistochemical techniques, using various kinds of monoclonal antikeratin antibodies. Comparative immunohistochemical observations of eccrine poroma and normal eccrine glands revealed that the poroma cells expressed immunophenotypes similar to those of the basal cells of dermal eccrine ducts. Sweat-ductlike structures showed similar staining patterns to those observed in the inner cells of dermal eccrine ducts. Some cystic spaces were similar to those observed in the secretory cells of eccrine glands. Eccrine poroma is, therefore, speculated to originate via the proliferation and expansion of the basal cells of eccrine ducts, although it is very difficult to prove the histogenesis. Some tumor cells may differentiate toward inner cells of the eccrine ducts, forming ductal lumina, whereas other tumor cells differentiate toward eccrine secretory regions, forming some cystic spaces.
S Watanabe; S Mogi; E Ichikawa; H Takahashi; H Minami; S Harada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  142     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-19     Completed Date:  1993-02-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  AIM; IM    
Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Adenoma, Sweat Gland / chemistry*,  pathology
Antibodies, Monoclonal
Eccrine Glands / chemistry,  pathology
Keratins / analysis*,  immunology
Staining and Labeling
Sweat Gland Neoplasms / chemistry*,  pathology
Reg. No./Substance:
0/Antibodies, Monoclonal; 68238-35-7/Keratins

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