Document Detail


Immunohistochemical analysis of the infiltrated cells in tinea capitis patients.
MedLine Citation:
PMID:  11990247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tinea capitis is a fungal infection of the skin and the hair with involvement of the hair shaft and the pilosebaceous unit. It may be the most common of all cutaneous mycoses in children. Tinea capitis can be inflammatory or noninflammatory. It is thought that humoral and cell-mediated immunities play a role in the formation of the clinical types of the disease. We studied twelve patients with acute inflammatory disease, four patients with chronic non-inflammatory disease, and one patient with a black-dot variant of tinea capitis. The composition of inflammatory infiltrates present in lesional skin was analyzed by antibodies to T cells (CD3) and B cells (CD20). Anti-CD3 revealed large numbers of T cells in twelve patients with acute, inflammatory dermatophytosis, whereas anti-CD20 revealed marked infiltrates of both B and T cells in all patients with chronic, non-inflammatory dermatophytosis. As a result, we thought that cell-mediated immunity might play a role in the acute, inflammatory type of tinea capitis and that humoral immunity might do so in the chronic, non-inflammatory type of tinea capitis.
Authors:
Mukadder Koçak; M Salih Deveci; Meral Ekşioğlu; Omer Günhan; Salime Yağli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  29     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-06     Completed Date:  2002-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Affiliation:
Ministry of Health, Ankara Education and Research Hospital, Department of Dermatology, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Antigens, CD20 / analysis
Antigens, CD3 / analysis
B-Lymphocytes / immunology*,  pathology
Child
Child, Preschool
Chronic Disease
Female
Humans
Immunity, Cellular
Immunohistochemistry
Male
Scalp / immunology*,  pathology
T-Lymphocytes / immunology*,  pathology
Tinea Capitis / immunology*,  pathology
Chemical
Reg. No./Substance:
0/Antigens, CD20; 0/Antigens, CD3

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