| Immunohistochemical analysis of in vivo UVB-induced secretion of IL-1α and IL-6 in keratinocytes. | |
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MedLine Citation:
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PMID: 21523320 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Keratinocytes play an important role in the inflammatory response of the skin. UVB stimulates keratinocytes to secrete several cytokines. To our knowledge, there are no reports that have examined which layer or cell type is responsible for producing these cytokines. Thus, in this study we performed immunohistochemical experiments to determine the potential cells or layers that express interleukin (IL)-1 and IL-6. The results show that the expression of IL-1α and IL-6 was induced 3 and 6 h after irradiation, respectively. Furthermore, IL-1α was maximally expressed earlier than IL-6, suggesting that IL-1α exists in the cytokine cascade of the UVB response upstream of IL-6. In addition, IL-1α expression began in the upper layers of the epidermis, whereas all layers expressed IL-6. This study provides further insight into the roles of cytokines in UVB-induced skin inflammation. |
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Authors:
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Narumi Hiromi; Hajime Nakano; Yasushi Matsuzaki; Daisuke Sawamura; Katumi Hanada |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-26 |
Journal Detail:
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Title: Molecular medicine reports Volume: - ISSN: 1791-3004 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Report Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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